Lou Jinchao, Hudson Macy M, Ancajas Christelle F, Best Michael D
Department of Chemistry, University of Tennessee, Knoxville, TN, 37996, USA.
Chem Commun (Camb). 2023 Mar 14;59(22):3285-3288. doi: 10.1039/d3cc00288h.
We report stimuli-responsive liposomes that selectively release encapsulated contents upon treatment with guanosine triphosphate (GTP) over a wide variety of phosphorylated metabolites, validated by fluorescence-based leakage assays. Significant changes in liposome self-assembly properties were also observed. Our results showcase the potential of this platform for triggered release applications.
我们报道了一种对刺激有响应的脂质体，在用三磷酸鸟苷（GTP）处理时，它能在多种磷酸化代谢物中选择性地释放包封的内容物，这通过基于荧光的泄漏测定得到了验证。同时还观察到脂质体自组装性质的显著变化。我们的结果展示了该平台在触发释放应用方面的潜力。
