Ortiz-Neu C, Marr J S, Cherubin C E, Neu H C
J Infect Dis. 1978 Dec;138(6):820-8. doi: 10.1093/infdis/138.6.820.
A search of the records at the New York City Department of Health and the charts of patients at Columbia Presbyterian Hospital identified 37 cases of bone infection and nine cases of joint infection due to Salmonella between 1964 and 1978. Factors that apparently contributed to the development of either osteomyelitis or septic arthritis in 23 of the patients included hemoglobinopathy, previous trauma or surgery, connective tissue disorder, and lymphoma. Salmonella typhimurium and Salmonella enteritidis were the most common serotypes involved with bone infections, whereas members of the C1 serogroup were the most common cause of septic joint infections. Isolates of C1 serogroup Salmonella were represented in both bone and joint infections with frequencies (24% and 67%, respectively) disproportionate to the numbers of Salmonella isolated from other sources during this period. Therapy for joint infections was usually successful, with minimal residual damage. Therapy for acute osteomyelitis was unaccountably inadequate, with many patients (47%) developing chronic infections. Use of inappropriate therapy or an insufficient period of therapy were the most important factors contributing to poor outcome.
对纽约市卫生部的记录以及哥伦比亚长老会医院患者病历的检索发现，1964年至1978年间有37例沙门氏菌引起的骨感染病例和9例关节感染病例。在23名患者中，明显促成骨髓炎或化脓性关节炎发生的因素包括血红蛋白病、既往创伤或手术、结缔组织疾病和淋巴瘤。鼠伤寒沙门氏菌和肠炎沙门氏菌是与骨感染相关的最常见血清型，而C1血清群成员是化脓性关节感染的最常见病因。C1血清群沙门氏菌分离株在骨感染和关节感染中均有出现，其频率（分别为24%和67%）与该时期从其他来源分离出的沙门氏菌数量不成比例。关节感染的治疗通常是成功的，残留损伤最小。急性骨髓炎的治疗却莫名其妙地不充分，许多患者（47%）发展为慢性感染。使用不恰当的治疗方法或治疗时间不足是导致预后不良的最重要因素。
