Department of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Department of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Brain Struct Funct. 2023 May;228(3-4):1033-1038. doi: 10.1007/s00429-023-02621-2. Epub 2023 Feb 24.
Neuroimaging studies in healthy and clinical populations strongly associate the amygdala with emotion, especially negative emotions. The consequences of surgical resection of the amygdala on mood are not well characterized. We tested the hypothesis that amygdala resection would result in mood improvement. In this study, we evaluated a cohort of 52 individuals with medial temporal lobectomy for intractable epilepsy who had resections variably involving the amygdala. All individuals achieved good post-surgical seizure control and had pre- and post-surgery mood assessment with the Beck Depression Inventory (BDI) ratings. We manually segmented the surgical resection cavities and performed multivariate lesion-symptom mapping of change in BDI. Our results showed a significant improvement in average mood ratings from pre- to post-surgery across all patients. In partial support of our hypothesis, resection of the right amygdala was significantly associated with mood improvement (r = 0.5, p = 0.008). The lesion-symptom map also showed that resection of the right hippocampus and para-hippocampal gyrus was associated with worsened post-surgical mood. Future studies could evaluate this finding prospectively in larger samples while including other neuropsychological outcome measures.
神经影像学研究在健康人群和临床人群中强烈地将杏仁核与情绪联系起来，特别是与负面情绪。杏仁核切除术对情绪的影响尚未得到很好的描述。我们检验了这样一个假设，即杏仁核切除术将导致情绪改善。在这项研究中，我们评估了 52 名因难治性癫痫接受内侧颞叶切除术的个体，这些个体的杏仁核切除术具有不同程度的涉及。所有患者在手术后都达到了良好的癫痫控制，并在术前和术后使用贝克抑郁量表 (BDI) 进行了情绪评估。我们手动分割手术切除腔，并对 BDI 变化进行了多元病变-症状映射。我们的结果表明，所有患者的平均情绪评分从术前到术后均显著改善。部分支持我们的假设，右侧杏仁核切除术与情绪改善显著相关 (r=0.5，p=0.008)。病变-症状图还显示，右侧海马体和海马旁回的切除术与术后情绪恶化有关。未来的研究可以在更大的样本中前瞻性地评估这一发现，同时包括其他神经心理学的结果衡量。
