Nurbyek Stipan, Buyankhishig Buyanmandakh, Suganuma Keisuke, Ishikawa Yoshinobu, Kutsuma Mika, Abe Marie, Sasaki Kenroh, Davaapurev Bekh-Ochir, Batkhuu Javzan, Murata Toshihiro
Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan; School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, 14201, Mongolia.
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.
Phytochemistry. 2023 May;209:113615. doi: 10.1016/j.phytochem.2023.113615. Epub 2023 Feb 23.
Scutellaria scordiifolia Fisch. ex Schrank is used to treat various inflammatory diseases and other ailments in traditional and contemporary medicine. In this study, 10 undescribed compounds, including a flavanone (1), four chrysin C-glycosides (2-5), a phenanthrene glucoside (6), four iridoid glucosides (7-10) and 31 known compounds were identified from an extract of the aerial parts of S. scordiifolia. The absolute configurations of sugars in C-glycosides were determined by comparing electric circular dichroism spectra with calculated data. The flavanones (1 and 17), flavonols (11-13), flavone (14), and some of the flavone glucuronides (15, 16) exhibited trypanocidal activities against Trypanosoma congolense. The activity data and quantitative HPLC analysis of flavonoids from the aerial parts of S. scordiifolia suggest that they may effectively treat diseases caused by the aforementioned trypanosomes. Other compounds such as novel iridoids and phenanthrene glycosides, which may be useful for chemophenetic and chemoecological discussions, were also identified.
Scutellaria scordiifolia Fisch. ex Schrank在传统医学和现代医学中都被用于治疗各种炎症性疾病和其他疾病。在本研究中，从Scutellaria scordiifolia地上部分的提取物中鉴定出10种未描述的化合物，包括一种黄烷酮（1）、四种白杨素C-糖苷（2-5）、一种菲糖苷（6）、四种环烯醚萜苷（7-10）以及31种已知化合物。通过将电圆二色光谱与计算数据进行比较，确定了C-糖苷中糖的绝对构型。黄烷酮（1和17）、黄酮醇（11-13）、黄酮（14）以及一些黄酮葡糖醛酸苷（15、16）对刚果锥虫表现出杀锥虫活性。Scutellaria scordiifolia地上部分黄酮类化合物的活性数据和定量HPLC分析表明，它们可能有效治疗由上述锥虫引起的疾病。还鉴定出了其他化合物，如新型环烯醚萜和菲糖苷，它们可能有助于化学分类学和化学生态学的讨论。
