Ni Yueqi, Zhang Hong, Chu Liang, Zhao Yin
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Antioxidants (Basel). 2023 Feb 17;12(2):510. doi: 10.3390/antiox12020510.
Oxidative stress (OS) refers to a state of imbalance between oxidation and antioxidation. OS is considered to be an important factor leading to aging and a range of diseases. The eyes are highly oxygen-consuming organs. Due to its continuous exposure to ultraviolet light, the eye is particularly vulnerable to the impact of OS, leading to eye diseases such as corneal disease, cataracts, glaucoma, etc. The N6-methyladenosine (m6A) modification is the most investigated RNA post-transcriptional modification and participates in a variety of cellular biological processes. In this study, we review the role of m6A modification in oxidative stress-induced eye diseases and some therapeutic methods to provide a relatively overall understanding of m6A modification in oxidative stress-related eye diseases.
氧化应激（OS）是指氧化与抗氧化之间失衡的一种状态。氧化应激被认为是导致衰老和一系列疾病的重要因素。眼睛是高耗氧器官。由于眼睛持续暴露于紫外线下，特别容易受到氧化应激的影响，从而引发角膜疾病、白内障、青光眼等眼部疾病。N6-甲基腺苷（m6A）修饰是研究最多的RNA转录后修饰，参与多种细胞生物学过程。在本研究中，我们综述了m6A修饰在氧化应激诱导的眼部疾病中的作用以及一些治疗方法，以期对m6A修饰在氧化应激相关眼部疾病中形成较为全面的认识。
Zotero 插件