Mantle David, Hargreaves Iain Parry
Pharma Nord (UK) Ltd., Morpeth NE61 2DB, UK.
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Merseyside L3 5UX, UK.
Antioxidants (Basel). 2023 Feb 17;12(2):514. doi: 10.3390/antiox12020514.
Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of a number of endocrine disorders; this, in turn, suggests a potential role for the vitamin-like substance coenzyme Q10 (CoQ10) in the pathogenesis and treatment of these disorders, on the basis of its key roles in mitochondrial function, and as an antioxidant. In this article we have therefore reviewed the role of CoQ10 deficiency and supplementation in disorders of the thyroid, pancreas, gonads, pituitary and adrenals, with a particular focus on hyperthyroidism, type II diabetes, male infertility and polycystic ovary syndrome.
线粒体功能障碍和氧化应激与多种内分泌疾病的发病机制有关；这进而提示，维生素样物质辅酶Q10（CoQ10）基于其在线粒体功能中的关键作用以及作为抗氧化剂的特性，在这些疾病的发病机制和治疗中可能发挥作用。因此，在本文中，我们综述了CoQ10缺乏及补充在甲状腺、胰腺、性腺、垂体和肾上腺疾病中的作用，尤其关注甲状腺功能亢进症、2型糖尿病、男性不育症和多囊卵巢综合征。
