Université de Poitiers, Laboratoire Lipotoxicity and Channelopathies (LiTch)-ConicMeds, 86073 Poitiers, France.
Université de Poitiers, Laboratoire PRéTI, 86073 Poitiers, France.
Biomolecules. 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342.
Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion channels (ASIC3). The aim of the present study was to investigate the lipid contents of the synovial fluids from controls and patients suffering from chronic joint pain in order to identify characteristic lipid signatures associated with specific joint diseases. For this purpose, lipids were extracted from the synovial fluids and analyzed by mass spectrometry. Lipidomic analyses identified certain choline-containing lipid classes and molecular species as biomarkers of chronic joint pain, regardless of the pathology, with significantly higher levels detected in the patient samples. Moreover, correlations were observed between certain lipid levels and the type of joint pathologies. Interestingly, LPC16:0 levels appeared to correlate with the metabolic status of patients while other choline-containing lipids were more specifically associated with the inflammatory state. Overall, these data point at selective lipid species in synovial fluid as being strong predictors of specific joint pathologies which could help in the selection of the most adapted treatment.
脂质，特别是溶血磷脂酰胆碱 LPC16:0，已被证明通过激活酸敏感离子通道（ASIC3）参与慢性关节疼痛。本研究旨在调查来自慢性关节疼痛患者和对照者的滑液中的脂质含量，以确定与特定关节疾病相关的特征脂质特征。为此，从滑液中提取脂质，并通过质谱进行分析。脂质组学分析确定了某些含有胆碱的脂质类和分子种类作为慢性关节疼痛的生物标志物，无论病理学如何，在患者样本中检测到的水平明显更高。此外，还观察到某些脂质水平与关节病变类型之间存在相关性。有趣的是，LPC16:0 水平似乎与患者的代谢状态相关，而其他含有胆碱的脂质则更具体地与炎症状态相关。总体而言，这些数据表明滑液中的选择性脂质种类是特定关节病变的强预测因子，这有助于选择最合适的治疗方法。
