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邻苯二甲酰亚胺衍生物的合成及其对加勒比水果蝇（Loew）的杀虫活性

Synthesis of Phthalimide Derivatives and Their Insecticidal Activity against Caribbean Fruit Fly, (Loew).

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkey.

Subtropical Horticulture Research Station (SHRS), United States Department of Agriculture-Agricultural Research Service (USDA-ARS), 13601 Old Cutler Rd., Miami, FL 33158, USA.

出版信息

Biomolecules. 2023 Feb 14;13(2):361. doi: 10.3390/biom13020361.

DOI:10.3390/biom13020361
PMID:36830730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9953367/
Abstract

In this study, thirteen phthalimide derivatives were designed and synthesized. All synthesized compounds were evaluated to determine their potential for inhibitory activities against females of the Caribbean fruit fly, (Loew) (Diptera: Tephritidae). These efforts led to the discovery of three compounds , , and with potent insecticidal activity (LD range from 0.70 to 1.91 μg/fly). Among these compounds, exhibited the highest inhibitory potency with 0.70 μg/fly. In addition, in silico models indicated that compound is less toxic than phthalimide and other precursors. Therefore, our results suggest that has strong potential as a candidate component for developing a novel environmentally friendly insecticide for control of pest fruit flies.

摘要

在这项研究中，设计和合成了 13 种邻苯二甲酰亚胺衍生物。评估了所有合成的化合物，以确定它们对加勒比水果蝇雌性（Loew）（双翅目：实蝇科）的抑制活性潜力。这些努力发现了三种化合物 、 和 ，具有很强的杀虫活性（LD 范围为 0.70 至 1.91 μg/蝇）。在这些化合物中， 表现出最高的抑制效力，为 0.70 μg/蝇。此外，计算机模型表明，化合物 比邻苯二甲酰亚胺和其他前体的毒性更小。因此，我们的结果表明， 具有作为开发新型环保杀虫剂控制害虫实蝇的候选成分的强大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/801237098345/biomolecules-13-00361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/845b9e253479/biomolecules-13-00361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/619284dc5681/biomolecules-13-00361-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/801237098345/biomolecules-13-00361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/845b9e253479/biomolecules-13-00361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/619284dc5681/biomolecules-13-00361-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fcb/9953367/801237098345/biomolecules-13-00361-g002.jpg

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