Tedeschi Dauar Marina, Pascoal Tharick Ali, Therriault Joseph, Rowley Jared, Mohaddes Sara, Shin Monica, Zimmer Eduardo R, Eskildsen Simon Fristed, Fonov Vladimir S, Gauthier Serge, Poirier Judes, Rosa-Neto Pedro
Douglas Mental Health University Institute, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Centre for the Studies in the Prevention of Alzheimer's Disease, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Brain Sci. 2023 Jan 30;13(2):232. doi: 10.3390/brainsci13020232.
Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer's disease (AD). In this study, we assessed patients' scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer's Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [F]florbetapir and [F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [F]FDG uptake, and RAVLT30 scores positively associated with [F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [F]florbetapir uptake in the right frontal lobe. For the AD group, [F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages.
病理生理事件与认知指标之间的关联为了解阿尔茨海默病(AD)临床进展过程中受影响的脑网络提供了线索。在本研究中,我们评估了患者在两项延迟情景记忆测试中的得分,并研究了它们与AD临床谱中区域淀粉样蛋白沉积和脑代谢的关联。我们评估了来自阿尔茨海默病神经影像倡议组织的参与者的临床、神经心理学、结构和正电子发射断层扫描(PET)基线指标。受试者被分类为认知正常(CN)、早期(EMCI)或晚期(LMCI)轻度认知障碍,或AD痴呆。感兴趣的记忆结果指标是逻辑记忆30分钟延迟回忆(LM30)和雷伊听觉词语学习测试30分钟延迟回忆(RAVLT30)。构建了基于体素的[F]氟比他哌和[F]FDG摄取率图,并计算了PET图像与认知得分之间的相关性。我们发现,EMCI个体的LM30得分与右侧顶枕区的[F]氟比他哌摄取呈负相关。LMCI个体的LM30得分与左侧颞叶[F]FDG摄取呈正相关,RAVLT30得分与左侧顶叶和右侧内嗅皮质的[F]FDG摄取呈正相关。此外,LMCI个体的LM30得分与右侧额叶的[F]氟比他哌摄取呈负相关。对于AD组,[F]FDG摄取与左侧颞叶的LM30以及右侧额叶的RAVLT30呈正相关,[F]氟比他哌摄取与右侧顶叶和左侧额叶的LM30得分呈负相关。结果表明,区域脑代谢与情景记忆缺陷严重程度之间的关联取决于临床疾病阶段,提示言语情景记忆缺陷、AD病理生理学和临床疾病阶段之间存在动态关系。