Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Alzheimers Dement. 2014 Jan;10(1):76-83. doi: 10.1016/j.jalz.2012.09.017. Epub 2013 Jan 30.
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.
The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years.
Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition.
SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
比较正常测试表现的晚期轻度认知障碍（LMCI）、早期轻度认知障碍（EMCI）和主观记忆障碍（SMI）患者发展为阿尔茨海默病（AD）痴呆的风险。
前瞻性队列研究的基线样本（n=2892）来自于认知和痴呆在初级保健患者中的德国研究，根据延迟回忆表现将无痴呆个体分为 LMCI、EMCI、SMI 和对照组。通过自我报告的与经历的记忆障碍相关的问题，将这些组进一步细分。在 6 年内评估 AD 痴呆的风险。
在所有组中，AD 痴呆的风险在 LMCI 中最高。在那些对自己的记忆障碍有自我报告的担忧的患者中，SMI 和 EMCI 与 AD 痴呆的风险增加相关。在那些没有担忧的亚组中，SMI 与 AD 痴呆的风险增加无关，但 EMCI 仍然是一种风险状态。
有自我报告担忧的 SMI 和 EMCI 与 AD 痴呆的风险相同，这表明应将 LMCI 之前的风险状态扩展到有担忧的 SMI。
