School of Nursing, Purdue University, West Lafayette, IN 47907, USA.
Department of Health Behavior, Texas A&M University, College Station, TX 77843, USA.
Int J Environ Res Public Health. 2023 Feb 15;20(4):3384. doi: 10.3390/ijerph20043384.
Breast cancer is the most commonly diagnosed cancer among Chinese American women. Knowing the BRCA1 and BRCA2 (BRCA1/2) gene mutation status can improve breast cancer patients' health outcomes by guiding targeted treatment towards preventing breast cancer recurrence and other BRCA-related cancers. Nevertheless, it is unclear if there is a disparity in knowledge and use of BRCA testing among Chinese American breast cancer patients. This cross-sectional study investigated the possible presence of differences in the knowledge and the use of BRCA testing between Chinese American and Non-Hispanic White (NHW) breast cancer patients. We surveyed 45 Chinese American and 48 NHW adult breast cancer patients who had been diagnosed with breast cancer within the previous two years through telephone interviews. The results showed that race was not statistically related to the use of BRCA testing. BRCA testing utilization was associated with family history ( < 0.05) and age ( < 0.05). However, Chinese American participants' understanding of BRCA testing was significantly lower than that of NHW participants ( = 0.030). Our findings suggest that a disparity exists in BRCA testing knowledge between Chinese American and NHW breast cancer patients. Genetic education and counseling are needed to improve BRCA testing knowledge and uptake among Chinese American breast cancer patients.
乳腺癌是美籍华裔女性中最常见的癌症。了解 BRCA1 和 BRCA2（BRCA1/2）基因突变状态可以通过指导针对预防乳腺癌复发和其他与 BRCA 相关癌症的靶向治疗来改善乳腺癌患者的健康结果。然而，目前尚不清楚美籍华裔乳腺癌患者在 BRCA 检测的知识和使用方面是否存在差异。这项横断面研究调查了美籍华裔和非西班牙裔白人（NHW）乳腺癌患者在 BRCA 检测的知识和使用方面是否存在差异。我们通过电话访谈调查了 45 名美籍华裔和 48 名 NHW 成年乳腺癌患者，这些患者在过去两年内被诊断出患有乳腺癌。结果表明，种族与 BRCA 检测的使用没有统计学上的关系。BRCA 检测的使用与家族史（<0.05）和年龄（<0.05）有关。然而，美籍华裔参与者对 BRCA 检测的理解明显低于 NHW 参与者（=0.030）。我们的研究结果表明，美籍华裔和 NHW 乳腺癌患者在 BRCA 检测知识方面存在差异。需要进行遗传教育和咨询，以提高美籍华裔乳腺癌患者对 BRCA 检测的知识和接受程度。
