Wirth S, Ehninger G, Baumann W
Kinderklinik der Johannes-Gutenberg-Universität Mainz.
Monatsschr Kinderheilkd. 1987 Oct;135(10):696-8.
We describe three newborns who developed varicella six hours, five or eight days after delivery. Because of the high lethality rate of congenital varicella treatment with acyclovir appeared to be indicated. Acyclovir was administered intravenously in a dosage of 3 X 5, 3 X 7.5, and 3 X 10 mg/kg/day for three to five days. All patients showed prompt clinical improvement and the skin lesions disappeared. Side effects were not observed. Dependent on the dosage radioimmunological determination of acyclovir serum levels revealed basic values between less than 0.34 to 13.9 mumol/l; peak levels ranged from 14.0 to 70.2 mumol/l. Our preliminary results demonstrate that acyclovir can be successfully used to treat congenital varicella. A dosage of at least 3 X 7.5 mg/kg/day is recommended.
我们描述了三名新生儿，他们在出生后6小时、5天或8天患上了水痘。由于先天性水痘的致死率很高，因此似乎需要用阿昔洛韦进行治疗。阿昔洛韦以3×5、3×7.5和3×10mg/kg/天的剂量静脉给药，持续三至五天。所有患者的临床症状均迅速改善，皮肤损伤消失。未观察到副作用。根据剂量，阿昔洛韦血清水平的放射免疫测定显示基本值低于0.34至13.9μmol/L；峰值水平为14.0至70.2μmol/L。我们的初步结果表明，阿昔洛韦可成功用于治疗先天性水痘。建议至少使用3×7.5mg/kg/天的剂量。
