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藻酸盐通过抑制 TLR4 信号通路保护心肌缺血再灌注损伤。

Alga Protects against Myocardial Ischemia/Reperfusion Injury by Attenuating TLR4 Signaling.

机构信息

Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.

School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

出版信息

Int J Mol Sci. 2023 Feb 15;24(4):3871. doi: 10.3390/ijms24043871.

DOI:10.3390/ijms24043871
PMID:36835281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9963554/
Abstract

Myocardial ischemia/reperfusion (I/R) injury is marked by rapid increase in inflammation and not only results in myocardial apoptosis but also compromises the myocardial function. (), a halophilic unicellular microalga, has been used as a provitamin A carotenoid supplement and color additive. Several studies have reported that extract could attenuate lipopolysaccharides-induced inflammatory effects and regulate the virus-induced inflammatory response in macrophages. However, the effects of on myocardial I/R injury remain unknown. Therefore, we aimed to investigate the cardioprotection of extract in rats subjected to myocardial I/R injury that was induced by occlusion of the left anterior descending coronary artery for 1 h followed by 3 h of reperfusion. Compared with the vehicle group, the myocardial infarct size significantly decreased in rats that were pre-treated with . significantly attenuated the expressions of TLR4, COX-2 and the activity of STAT1, JAK2, IκB, NF-κB. Furthermore, significantly inhibited the activation of caspase-3 and the levels of Beclin-1, p62, LC3-I/II. This study is the first to report that the cardioprotective effects of may mediate anti-inflammatory and anti-apoptotic activities and decrease autophagy through the TLR4-mediated signaling pathway to antagonize myocardial I/R injury.

摘要

心肌缺血/再灌注 (I/R) 损伤的特征是炎症迅速增加，不仅导致心肌细胞凋亡，还损害心肌功能。盐生杜氏藻（Dunaliella salina）是一种嗜盐单细胞微藻，一直被用作维生素 A 前体类胡萝卜素补充剂和着色剂。多项研究报道，盐生杜氏藻提取物可减轻脂多糖诱导的炎症作用，并调节巨噬细胞中病毒诱导的炎症反应。然而，盐生杜氏藻提取物对心肌 I/R 损伤的影响尚不清楚。因此，我们旨在研究盐生杜氏藻提取物对左前降支冠状动脉结扎 1 小时再灌注 3 小时诱导的心肌 I/R 损伤大鼠的心脏保护作用。与对照组相比，预先用盐生杜氏藻提取物处理的大鼠心肌梗死面积明显减小。盐生杜氏藻提取物显著降低了 TLR4、COX-2 的表达以及 STAT1、JAK2、IκB、NF-κB 的活性。此外，盐生杜氏藻提取物显著抑制了 caspase-3 的激活和 Beclin-1、p62、LC3-I/II 的水平。这项研究首次报道，盐生杜氏藻的心脏保护作用可能通过 TLR4 介导的信号通路介导抗炎和抗凋亡活性，并减少自噬来拮抗心肌 I/R 损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/f4021f04acd0/ijms-24-03871-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/82adf2150ba3/ijms-24-03871-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/71f4b76bd63f/ijms-24-03871-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/ea9c1478f80a/ijms-24-03871-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/b42bf35d2e7b/ijms-24-03871-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/f4021f04acd0/ijms-24-03871-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/82adf2150ba3/ijms-24-03871-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/71f4b76bd63f/ijms-24-03871-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/ea9c1478f80a/ijms-24-03871-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/b42bf35d2e7b/ijms-24-03871-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/9963554/f4021f04acd0/ijms-24-03871-g005.jpg

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