表观遗传调控睾丸肿瘤发生中的驱动基因。
Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis.
机构信息
Center for Tobacco Control Research, Birkevej 17, 5230 Odense, Denmark.
Laboratory of Genomics and Molecular Biomedicine, August Krogh Building Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark.
出版信息
Int J Mol Sci. 2023 Feb 19;24(4):4148. doi: 10.3390/ijms24044148.
In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/ and and embryonal carcinoma (EC) has four upregulated genes, OCT4/ and The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general.
在睾丸生殖细胞肿瘤 II 型（TGCT）中，精原细胞瘤亚型表达诱导多能干细胞（iPSC）面板，其中四个上调基因是 OCT4/ 和 ，胚胎癌（EC）有四个上调基因，OCT4/ 和 。EC 面板可以将细胞重编程为 iPSC，iPSC 和 EC 都可以分化为畸胎瘤。这篇综述总结了关于这些基因的表观遗传调控的文献。表观遗传机制，如 DNA 链上胞嘧啶的甲基化和组蛋白 3 赖氨酸的甲基化和乙酰化，调节这些驱动基因在 TGCT 亚型之间的表达。在 TGCT 中，驱动基因与众所周知的临床特征有关，驱动基因对于许多其他恶性肿瘤的侵袭性亚型也很重要。总之，驱动基因的表观遗传调控对 TGCT 乃至整个肿瘤学都很重要。
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