Xu Shijun, Wu Zining, Liu Yongmin, Zhu Junming, Gong Ming, Sun Lizhong, Ran Dong, Zhang Hongjia
Beijing Aortic Disease Center, Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing 100029, China.
Beijing Laboratory for Cardiovascular Precision Medicine, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University, Beijing 100029, China.
J Clin Med. 2023 Feb 16;12(4):1581. doi: 10.3390/jcm12041581.
There are relatively few articles on the relationship between serum albumin and acute kidney injury (AKI). Therefore, the objective of this research was to study the relationship between serum albumin and AKI in patients who were undergoing surgery for acute type A aortic dissection.
We retrospectively collected data from 624 patients attending a Chinese hospital between January 2015 and June 2017. The target independent variable was serum albumin measured before surgery after hospital admission, and the dependent variable was AKI, defined in accordance with the Kidney Disease Improving Global Outcomes (KDIGO) criteria.
The mean age of these 624 selected patients was 48.5 ± 11.1 years, and almost 73.7% were male. A nonlinear association was detected between serum albumin and AKI; the turning point was 32 g/L. The risk of AKI decreased gradually as the serum albumin level increased up to 32 g/L (adjusted OR = 0.87; 95% CI 0.82-0.92; < 0.001). When the serum albumin level exceeded 32 g/L, the level of serum albumin was not associated with the risk of AKI (OR = 1.01, 95% CI 0.94-1.08; = 0.769).
The findings suggest that preoperative serum albumin below 32 g/L was an independent risk factor for AKI in patients undergoing surgery for acute type A aortic dissection.
A retrospective cohort study.
关于血清白蛋白与急性肾损伤（AKI）之间关系的文章相对较少。因此，本研究的目的是探讨急性A型主动脉夹层手术患者血清白蛋白与AKI之间的关系。
我们回顾性收集了2015年1月至2017年6月在中国一家医院就诊的624例患者的数据。目标自变量是入院后手术前测量的血清白蛋白，因变量是根据改善全球肾脏病预后组织（KDIGO）标准定义的AKI。
这624例入选患者的平均年龄为48.5±11.1岁，近73.7%为男性。血清白蛋白与AKI之间存在非线性关联；转折点为32 g/L。随着血清白蛋白水平升高至32 g/L，AKI风险逐渐降低（调整后OR=0.87；95%CI 0.82-0.92；<0.001）。当血清白蛋白水平超过32 g/L时，血清白蛋白水平与AKI风险无关（OR=1.01，95%CI 0.94-1.08；=0.769）。
研究结果表明，术前血清白蛋白低于32 g/L是急性A型主动脉夹层手术患者发生AKI的独立危险因素。
一项回顾性队列研究。
