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探索抗癌治疗的心脏毒性谱:定义、分类及诊断途径

Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways.

作者信息

Mauro Ciro, Capone Valentina, Cocchia Rosangela, Cademartiri Filippo, Riccardi Ferdinando, Arcopinto Michele, Alshahid Maie, Anwar Kashif, Carafa Mariano, Carbone Andreina, Castaldo Rossana, Chianese Salvatore, Crisci Giulia, D'Assante Roberta, De Luca Mariarosaria, Franzese Monica, Galzerano Domenico, Maffei Vincenzo, Marra Alberto Maria, Mazza Alfredo, Ranieri Brigida, D'Agostino Anna, Rega Salvatore, Romano Luigia, Scagliarini Sarah, Sepe Chiara, Vriz Olga, Izzo Raffaele, Cittadini Antonio, Bossone Eduardo, Salzano Andrea

机构信息

Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, Italy.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Sergio Pansini, 5, 80131 Naples, Italy.

出版信息

J Clin Med. 2023 Feb 17;12(4):1612. doi: 10.3390/jcm12041612.

DOI:10.3390/jcm12041612
PMID:36836147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9962102/
Abstract

Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clinical index of suspicion is required by the multidisciplinary care team in order to trigger specific laboratory tests (namely natriuretic peptides and high-sensitivity cardiac troponin) and appropriate imaging techniques (transthoracic echocardiography along with cardiac magnetic resonance, cardiac computed tomography, and nuclear testing (if clinically indicated)), leading to timely diagnosis. In the near future, we do expect a more tailored approach to patient care within the respective community along with the widespread implementation of digital health tools.

摘要

癌症的早期检测和治疗已使死亡率和发病率显著降低。然而,化疗和放疗可能会产生心血管(CV)副作用,影响生存和生活质量,且与肿瘤预后无关。在这方面,多学科护理团队需要有较高的临床怀疑指数,以便启动特定的实验室检查(即利钠肽和高敏心肌肌钙蛋白)以及适当的成像技术(经胸超声心动图以及心脏磁共振成像、心脏计算机断层扫描和核素检查(如临床有指征)),从而实现及时诊断。在不久的将来,我们确实期望在各自的社区内对患者护理采取更具针对性的方法,并广泛应用数字健康工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/82956c524a9a/jcm-12-01612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/20a8a48bee0e/jcm-12-01612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/1ffb0b538c82/jcm-12-01612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/95afbdf707e7/jcm-12-01612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/82956c524a9a/jcm-12-01612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/20a8a48bee0e/jcm-12-01612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/1ffb0b538c82/jcm-12-01612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/95afbdf707e7/jcm-12-01612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c3/9962102/82956c524a9a/jcm-12-01612-g004.jpg

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2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.2022 年国际癌症患者静脉血栓栓塞症治疗和预防临床实践指南,包括 COVID-19 患者。
Lancet Oncol. 2022 Jul;23(7):e334-e347. doi: 10.1016/S1470-2045(22)00160-7.
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Cardiovascular Imaging in Cardio-Oncology: The Role of Echocardiography and Cardiac MRI in Modern Cardio-Oncology.心血管肿瘤学中的心血管影像学:超声心动图和心脏 MRI 在现代心血管肿瘤学中的作用。
Heart Fail Clin. 2022 Jul;18(3):455-478. doi: 10.1016/j.hfc.2022.02.007.
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