Onwuka Oluchukwu, Saddemi Jackson L, Akkan Aydoğmuş Fatma Sema, Lasalle Claudia C, Ramsey David J
Department of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USA.
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA.
Life (Basel). 2023 Jan 31;13(2):385. doi: 10.3390/life13020385.
This study investigated whether the interval of monitoring at-risk, fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) has any bearing on the severity of the disease at the time of diagnosis. The study comprised a retrospective, cross-sectional comparative case series of treatment-naïve eyes in patients who were diagnosed sequentially with nAMD. We compared the visual acuity (VA) and central macular thickness (CMT) of patients who were actively receiving intravitreal injections (IVIs) of anti-vascular endothelial growth factor (anti-VEGF) agents at the time of second eye diagnosis with the VA and CMT of patients who had ceased treatment in their first eye because of reaching end-stages of disease. Intervals of visits and frequency of monitoring the macula of fellow eyes by means of optical coherence tomography (OCT) were abstracted from the medical record. We found that the at-risk fellow eyes of patients who had stopped treatment for nAMD in their first eye prior to fellow eye conversion were monitored significantly less frequently than the fellow eyes of patients who continued to receive treatment at the time of second eye diagnosis. Despite less frequent monitoring, VA and CMT were similar at the time of fellow eye diagnosis for both groups.
本研究调查了单侧新生血管性年龄相关性黄斑变性（nAMD）患者的高危对侧眼的监测间隔是否与诊断时疾病的严重程度有关。该研究包括一个回顾性、横断面比较病例系列，研究对象为先后被诊断为nAMD的初治患者的眼睛。我们比较了在第二只眼诊断时正在接受玻璃体内注射抗血管内皮生长因子（抗VEGF）药物治疗的患者的视力（VA）和中心黄斑厚度（CMT），以及因疾病达到终末期而停止第一只眼治疗的患者的VA和CMT。通过光学相干断层扫描（OCT）对黄斑进行检查的就诊间隔和监测频率从病历中提取。我们发现，在对侧眼发生病变之前，第一只眼已停止治疗的nAMD患者的高危对侧眼的监测频率明显低于第二只眼诊断时仍在接受治疗的患者的对侧眼。尽管监测频率较低，但两组对侧眼诊断时的VA和CMT相似。
