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具有神经内分泌特征的乳腺癌的临床病理特征及预后分析

Clinicopathological Characteristics and Prognostic Profiles of Breast Carcinoma with Neuroendocrine Features.

作者信息

Qiu Yue, Dai Yongjing, Zhu Li, Hao Xiaopeng, Zhang Liping, Bao Baoshi, Chen Yuhui, Wang Jiandong

机构信息

Graduate School, Chinese PLA Medical School, Beijing 100853, China.

Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

出版信息

Life (Basel). 2023 Feb 15;13(2):532. doi: 10.3390/life13020532.

DOI:10.3390/life13020532
PMID:36836889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9967167/
Abstract

BACKGROUND

Breast carcinoma with neuroendocrine features includes neuroendocrine neoplasm of the breast and invasive breast cancer with neuroendocrine differentiation. This study aimed to investigate the clinicopathological features and prognosis of this disease according to the fifth edition of the World Health Organization classification of breast tumors.

MATERIALS AND METHODS

A total of 87 patients with breast carcinoma with neuroendocrine features treated in the First Medical Center, Chinese PLA General Hospital from January 2001 to January 2022 were retrospectively enrolled in this study.

RESULTS

More than half of the patients were postmenopausal patients, especially those with neuroendocrine neoplasm (62.96%). There were more patients with human epidermal growth factor receptor 2 negative and hormone receptor positive tumors, and most of them were Luminal B type (71.26%). The multivariate analysis showed that diabetes and stage IV disease were related to the progression-free survival of breast carcinoma with neuroendocrine features patients ( = 0.004 and < 0.001, respectively).

CONCLUSION

Breast carcinoma with neuroendocrine features tended to be human epidermal growth factor receptor 2 negative and hormone receptor positive tumors, most of them were Luminal B type, and the related factors of progression-free survival were diabetes and stage IV disease.

摘要

背景

具有神经内分泌特征的乳腺癌包括乳腺神经内分泌肿瘤和具有神经内分泌分化的浸润性乳腺癌。本研究旨在根据世界卫生组织第五版乳腺肿瘤分类来调查该疾病的临床病理特征和预后。

材料与方法

回顾性纳入2001年1月至2022年1月在中国人民解放军总医院第一医学中心接受治疗的87例具有神经内分泌特征的乳腺癌患者。

结果

超过半数患者为绝经后患者，尤其是神经内分泌肿瘤患者（62.96%）。人表皮生长因子受体2阴性且激素受体阳性肿瘤的患者更多，且大多数为Luminal B型（71.26%）。多因素分析显示，糖尿病和IV期疾病与具有神经内分泌特征的乳腺癌患者的无进展生存期相关（分别为 = 0.004和 < 0.001）。

结论

具有神经内分泌特征的乳腺癌倾向于人表皮生长因子受体2阴性且激素受体阳性肿瘤，大多数为Luminal B型，无进展生存期的相关因素为糖尿病和IV期疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/a27e4e13cebd/life-13-00532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/31383621036d/life-13-00532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/59f93e768d9e/life-13-00532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/32a4fc61758d/life-13-00532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/a27e4e13cebd/life-13-00532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/31383621036d/life-13-00532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/59f93e768d9e/life-13-00532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/32a4fc61758d/life-13-00532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeba/9967167/a27e4e13cebd/life-13-00532-g004.jpg

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