用于便携式生物应用的高性价比微滴发生器。
Cost-Effective Droplet Generator for Portable Bio-Applications.
作者信息
Du Lin, Li Yuxin, Wang Jie, Zhou Zijian, Lan Tian, Jing Dalei, Wu Wenming, Zhou Jia
机构信息
School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai 200433, China.
School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200433, China.
出版信息
Micromachines (Basel). 2023 Feb 17;14(2):466. doi: 10.3390/mi14020466.
The convenient division of aqueous samples into droplets is necessary for many biochemical and medical analysis applications. In this article, we propose the design of a cost-effective droplet generator for potential bio-chemical application, featuring two symmetric tubes. The new droplet generator revisits the relationship between capillary components and liquid flow rates. The size of generated droplets by prototype depends only on generator dimensions, without precisely needing to control external flow conditions or driving pressure, even when the relative extreme difference in flow rate for generating nL level droplets is over 57.79%, and the relative standard deviation (RSD) of the volume of droplets is barely about 9.80%. A dropper working as a pressure resource is used to verify the rapidity and robustness of this principle of droplet generation, which shows great potential for a wide range of droplet-based applications.
将水性样品方便地分割成液滴对于许多生化和医学分析应用来说是必要的。在本文中，我们提出了一种用于潜在生化应用的经济高效的液滴发生器的设计，其具有两个对称的管子。这种新型液滴发生器重新审视了毛细管组件与液体流速之间的关系。原型产生的液滴大小仅取决于发生器的尺寸，甚至在产生纳升级液滴的流速相对极端差异超过57.79%时，也无需精确控制外部流动条件或驱动压力，并且液滴体积的相对标准偏差（RSD）仅约为9.80%。使用滴管作为压力源来验证这种液滴产生原理的快速性和稳健性，这表明其在广泛的基于液滴的应用中具有巨大潜力。
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