Liang Junyi, Wang Jiakun, Yao Wenjuan, Wang Mianzhi
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.
School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China.
Micromachines (Basel). 2023 Feb 19;14(2):483. doi: 10.3390/mi14020483.
Due to ethical issues and the nature of the ear, it is difficult to directly perform experimental measurements on living body elements of the human ear. Therefore, a numerical model has been developed to effectively assess the effect of the replacement of artificial ossicles on hearing in the inner ear. A healthy volunteer's right ear was scanned to obtain CT data, which were digitalized through the use of a self-compiling program and coalescent Patran-Nastran software to establish a 3D numerical model of the whole ear, and a frequency response of a healthy human ear was analyzed. The vibration characteristics of the basilar membrane (BM) after total ossicular replacement prosthesis (TORP) implantation were then analyzed. The results show that although the sound conduction function of the middle ear was restored after replacement of the TORP, the sensory sound function of the inner ear was affected. In the low frequency and medium frequency range, hearing loss was 5.2~10.7%. Meanwhile, in the middle-high frequency range, the replacement of a middle ear TORP in response to high sound pressure produced a high acoustic stimulation effect in the inner ear, making the inner ear structures susceptible to fatigue and more prone to fatigue damage compared to the structures in healthy individuals. This developed model is able to assess the effects of surgical operation on the entire hearing system.
由于伦理问题以及耳朵的特性，很难直接对人耳的活体组织进行实验测量。因此，已开发出一种数值模型，以有效评估人工听骨置换对内耳听力的影响。对一名健康志愿者的右耳进行扫描以获取CT数据，通过使用自编程序和联合使用Patran-Nastran软件将这些数据数字化，从而建立全耳的三维数值模型，并分析健康人耳的频率响应。然后分析了全听骨置换假体（TORP）植入后基底膜（BM）的振动特性。结果表明，虽然在置换TORP后中耳的声音传导功能得以恢复，但内耳的感觉声音功能受到了影响。在低频和中频范围内，听力损失为5.2%至10.7%。同时，在中高频范围内，中耳TORP对高声压的置换在内耳中产生了高声刺激效果，与健康个体的结构相比，使内耳结构更容易疲劳且更易发生疲劳损伤。所开发的该模型能够评估手术操作对整个听力系统的影响。
