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灵芝的药理学特性和生物活性成分的综合评价

A Comprehensive Review of the Pharmacological Properties and Bioactive Components of .

机构信息

Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco.

Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran.

出版信息

Molecules. 2023 Feb 10;28(4):1708. doi: 10.3390/molecules28041708.

Abstract

L. (Boiss.) or L. (Lam.), known locally as "R'tam", is a spontaneous and annual herb that belongs to the Fabaceae family. It is native to the Mediterranean regions, specifically in the desert areas and across the Middle Atlas in Morocco. This plant has been extensively used in folk medicine and it is rich in bioactive compounds, including polyphenols, flavonoids, and alkaloids. Current research efforts are focusing on the development of novel natural drugs as alternatives to various organic and non-organic chemical products from . In addition, extract, and isolated compounds obtained from different parts of the chosen plant have been described to exhibit multiple biological and pharmacological properties such as antioxidant, anti-aging, anti-inflammatory, antihypertensive, anti-helminthic, disinfectant, diuretic, and hypoglycemic effects. The plant-derived extract also acts as an antimicrobial agent, which is highly efficient in the treatment of bacterial, viral, and fungal infections. Its antiproliferative effects are associated with some mechanisms, such as the inhibition of cell cycle arrest and apoptosis. In light of these assessments, we critically highlight the beneficial effects of the flowers, stems, seeds extracts, and isolated compounds from (L.) Boiss in human health care, industrial, and other applications, as well as the possible ways to be employed as a potential natural source for future drug discovery.

摘要

(L.) 或 L. (Lam.),俗称“R'tam”,是一种自发的一年生草本植物,属于豆科。它原产于地中海地区,特别是在摩洛哥的沙漠地区和中阿特拉斯山脉。这种植物在民间医学中被广泛使用,它富含生物活性化合物,包括多酚、类黄酮和生物碱。目前的研究重点是开发新型天然药物,以替代各种有机和非有机化学产品。此外,从选定植物的不同部位提取和分离得到的化合物已被描述为具有多种生物和药理特性,如抗氧化、抗衰老、抗炎、降压、抗寄生虫、消毒、利尿和降血糖作用。植物提取物还具有抗菌作用,在治疗细菌、病毒和真菌感染方面非常有效。其抗增殖作用与一些机制有关,如抑制细胞周期停滞和细胞凋亡。有鉴于此,我们批判性地强调了 (L.) 博伊斯的花朵、茎、种子提取物和分离化合物在人类保健、工业和其他应用中的有益作用,以及作为未来药物发现的潜在天然来源的可能用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f17/9962008/311fb3bf910c/molecules-28-01708-g001.jpg

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