Ferlak Jan, Guzenda Weronika, Osmałek Tomasz
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland.
Pharmacy Practice Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland.
Pharmaceutics. 2023 Jan 20;15(2):361. doi: 10.3390/pharmaceutics15020361.
Orodispersible Films (ODFs) are drug delivery systems manufactured with a wide range of methods on a big scale or for customized medicines and small-scale pharmacy. Both ODFs and their fabrication methods have certain limitations. Many pharmaceutical companies and academic research centers across the world cooperate in order to cope with these issues and also to find new formulations for a wide array of APIs what could make their work profitable for them and beneficial for patients as well. The number of pending patent applications and granted patents with their innovative approaches makes the progress in the manufacturing of ODFs unquestionable. The number of commercially available ODFs is still growing. However, some of them were discontinued and are no longer available on the markets. This review aims to summarize currently marketed ODFs and those withdrawn from sale and also provides an insight into recently published studies concerning orodispersible films, emphasizing of utilized APIs. The work also highlights the attempts of scientific communities to overcome ODF's manufacturing methods limitations.
口腔崩解膜（ODFs）是一种药物递送系统，可通过多种方法大规模生产，也可用于定制药品和小型药房。ODFs及其制造方法都有一定的局限性。世界各地的许多制药公司和学术研究中心进行合作，以应对这些问题，并为各种各样的活性药物成分（APIs）寻找新的配方，这既能使他们的工作有利可图，也能使患者受益。 pending patent applications和授权专利的创新方法数量使得ODFs制造方面的进展毋庸置疑。市售ODFs的数量仍在增长。然而，其中一些已停产，不再在市场上销售。本综述旨在总结目前市场上销售的ODFs以及那些已退市的产品，并深入探讨最近发表的关于口腔崩解膜的研究，重点关注所使用的活性药物成分。这项工作还强调了科学界克服ODFs制造方法局限性的尝试。 （注：原文中“pending patent applications”未准确翻译，可能是“待决专利申请”之类的意思，但根据上下文不太能确定准确中文表述，暂保留英文。）
