浦肯野细胞变性突变小鼠的延迟自发交替行为

Delayed spontaneous alternation in Purkinje cell degeneration mutant mice.

作者信息

Lalonde R, Manseau M, Botez M I

机构信息

Hôtel-Dieu Hospital, Neurology Service, Montreal, Que., Canada.

出版信息

Neurosci Lett. 1987 Oct 5;80(3):343-6. doi: 10.1016/0304-3940(87)90479-4.

DOI:10.1016/0304-3940(87)90479-4

PMID:3683990

Abstract

Purkinje cell degeneration (pcd) mutant mice lose cerebellar Purkinje cells. It was found that pcd mice, contrary to normal mice, did not alternate spontaneously at any of 3 inter-trial intervals (15 s, 3 or 6 min). Deficits in spontaneous alternation are typical of animals with brain damage in areas important in spatial learning. Results are discussed in terms of a role for the cerebellum in spatially mediated behavior and behavioral inhibition.

摘要

浦肯野细胞变性（pcd）突变小鼠会丧失小脑浦肯野细胞。研究发现，与正常小鼠相反，pcd小鼠在3个试验间隔（15秒、3分钟或6分钟）中的任何一个时间点都不会自发交替。自发交替行为的缺陷是在空间学习中起重要作用的脑区受损动物的典型表现。本文从小脑在空间介导行为和行为抑制中的作用方面对研究结果进行了讨论。