Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Graduate School of Jinzhou Medical University, Jinzhou, Liaoning, China.
Cell Transplant. 2023 Jan-Dec;32:9636897231151576. doi: 10.1177/09636897231151576.
Organ transplantation has been linked to certain gene polymorphisms. The effect of gene polymorphisms-associated organ transplantation gene on infection, on the other hand, is yet unknown. The research studying the link between the CTLA-4 rs5742909, rs733618, rs4553808, rs231775, and polymorphisms of the organ transplantation gene and infection were found in PubMed, Web of Science, Scopus, and Embase, and the published articles from 2012 to 2020 were gathered. For the best estimation of the intended results, a random-effects model was used in this meta-analysis. In this study, 1,567 studies were initially included and 9 eligible studies were eligible for further analyses. A significant correlation between CTLA4+49 [A/G-231775 odds ratio (OR) = 077, 0.59-0.95] and CTLA4 [rs5742909TT OR: 0.09, 0.27-0.45] gene polymorphism with infection in organ transplantation was observed. Also, no significant association was found between other CTLA4 gene polymorphisms with infection in organ transplantation. Further studies involving gene-gene and gene-diet interactions should be conducted to investigate this association with infection.
器官移植与某些基因多态性有关。另一方面，基因多态性相关的器官移植基因对感染的影响尚不清楚。研究人员在 PubMed、Web of Science、Scopus 和 Embase 中搜索了与 CTLA-4 rs5742909、rs733618、rs4553808、rs231775 以及器官移植基因多态性与感染相关的研究，并收集了 2012 年至 2020 年发表的文章。为了最佳估计预期结果，本荟萃分析采用了随机效应模型。在这项研究中，最初纳入了 1567 项研究，有 9 项符合条件的研究可进一步进行分析。CTLA4+49 [A/G-231775 比值比 (OR) = 0.77, 0.59-0.95] 和 CTLA4 [rs5742909TT OR：0.09, 0.27-0.45] 基因多态性与器官移植感染之间存在显著相关性。此外，其他 CTLA4 基因多态性与器官移植感染之间没有显著相关性。应进行涉及基因-基因和基因-饮食相互作用的进一步研究，以调查这种与感染的相关性。
