Terada K, Morley G W
Department of Obstetrics and Gynecology, Women's Hospital, University of Michigan Medical Center, Ann Arbor.
Obstet Gynecol. 1987 Dec;70(6):913-5.
Fourteen patients with recurrent or second primary gynecologic malignancies after pelvic irradiation underwent radical hysterectomy as surgical salvage therapy. Six patients had microscopic regional metastatic disease at the time of surgery. All of these patients died of recurrent tumor. Overall disease-free actuarial survival at five years was 27%; excluding patients with regional metastatic disease, five-year survival was 54%. Complications requiring subsequent major surgical intervention occurred in 29% of patients. There appears to be a limited role for radical hysterectomy as surgical salvage therapy in patients with centrally limited invasive disease after pelvic irradiation.
14例盆腔放疗后复发或发生第二原发性妇科恶性肿瘤的患者接受了根治性子宫切除术作为手术挽救治疗。6例患者在手术时存在显微镜下区域转移病灶。所有这些患者均死于肿瘤复发。5年时总的无病精算生存率为27%；排除有区域转移病灶的患者后，5年生存率为54%。29%的患者发生了需要后续进行重大手术干预的并发症。对于盆腔放疗后中心性局限性浸润性疾病患者，根治性子宫切除术作为手术挽救治疗的作用似乎有限。
