Raza Hussain Ahmed, Raja Mohummad Hassan Raza, Bain Paul Arthur, Bedi Harmeet, Salam Rehana, Jamil Bushra, Shafiq Majid
The Aga Khan University, Karachi.
4th Year MBBS Student, The Aga Khan University, Karachi, Pakistan.
J Pak Med Assoc. 2023 Jan;73(1):98-105. doi: 10.47391/JPMA.5668.
To investigate the diagnostic performance of bronchoscopy in patients with coronavirus disease 2019 infection.
The systematic review was conducted in April 2021 and comprised search of published articles and preprint servers for original articles assessing diagnostic performance of bronchoscopy in patients with suspected coronavirus disease 2019 infection. The primary outcome of interest was diagnostic sensitivity of bronchoalveolar lavage in the patients. The quality of each study was assessed using the Quality Assessment, Data Abstraction and Synthesis-2 tool.
Of the 29 full-text articles assessed for eligibility, 4(13.8%) were included collectively comprising 209 patients who had undergone bronchoalveolar lavage. Mean sensitivity of bronchoalveolar lavage was 83.5% ± 10.63 (range: 68.2-940%). Overall, the 4 studies had an unclear or low risk of bias.
Limited data suggested that bronchoscopy with bronchoalveolar lavage did not have reliably higher diagnostic sensitivity than that reported for either nasopharyngeal or oropharyngeal swabs.
探讨支气管镜检查对2019冠状病毒病感染患者的诊断效能。
于2021年4月进行系统评价，检索已发表文章和预印本服务器，查找评估支气管镜检查对疑似2019冠状病毒病感染患者诊断效能的原始文章。感兴趣的主要结局是患者支气管肺泡灌洗的诊断敏感性。使用质量评估、数据提取与合成-2工具评估每项研究的质量。
在评估合格性的29篇全文文章中，共纳入4篇（13.8%），包括209例行支气管肺泡灌洗的患者。支气管肺泡灌洗的平均敏感性为83.5%±10.63（范围：68.2-94.0%）。总体而言，这4项研究存在不明确或低偏倚风险。
有限的数据表明，支气管镜检查联合支气管肺泡灌洗的诊断敏感性并不比鼻咽拭子或口咽拭子更高。
