Hill Emmeline W, McGivney Beatrice A, MacHugh David E
Plusvital Ltd., The Highline, Dun Laoghaire Industrial Estate, Dublin, Ireland.
UCD School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
Anim Genet. 2023 Jun;54(3):408-411. doi: 10.1111/age.13309. Epub 2023 Feb 26.
The proportion of the genome containing runs of homozygosity (ROH) affects production traits in livestock populations. In European and Australasian Thoroughbreds inbreeding, quantified using ROH (F ), is associated with the probability of ever racing. Here, we measured F using 333 K SNP genotypes from 768 Thoroughbred horses born in North America to evaluate the effect of inbreeding on racing traits in that region. Among North American horses, F was not associated (p = 0.518) with the probability of ever racing but was significantly associated with the number of race starts (p = 0.002). Among raced horses, those with a 10% higher F than the mean inbreeding coefficient were predicted to have 3.5 fewer race starts compared to horses with a mean inbreeding coefficient. Considering the trend of increasing inbreeding and a decline in the average number of race starts per runner in North America, mitigating inbreeding in the population could positively influence racing durability.
基因组中纯合子片段（ROH）的比例会影响家畜群体的生产性状。在欧洲和澳大拉西亚的纯种马中，使用ROH（F）量化的近交与参赛概率相关。在此，我们利用来自768匹出生于北美的纯种马的333K SNP基因型来测量F，以评估近交对该地区赛马性状的影响。在北美马匹中，F与参赛概率无关（p = 0.518），但与参赛次数显著相关（p = 0.002）。在参赛马匹中，近交系数比平均近交系数高10% 的马匹预计比平均近交系数的马匹参赛次数少3.5次。考虑到北美近交增加的趋势以及每匹马平均参赛次数下降的情况，减轻群体中的近交可能会对赛马耐力产生积极影响。
