抗利尿激素不适当分泌综合征（SIADH）伴严重低钠血症作为新冠病毒感染的首发及唯一表现：一例报告及病理生理学见解
Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) With Severe Hyponatremia As the Initial and Sole Presentation of COVID-19 Infection: A Case Report and Pathophysiologic Insights.
作者信息
Ayat Parinaz, Alam Sultana, Capric Violeta, Chen James, McFarlane Samy I
机构信息
Department of Medicine, Downstate-Health Science University, Brooklyn, USA.
Department of Internal Medicine: Endocrinology, Diabetes and Metabolism, Downstate-Health Science University, Brooklyn, USA.
出版信息
Cureus. 2023 Jan 24;15(1):e34161. doi: 10.7759/cureus.34161. eCollection 2023 Jan.
Hyponatremia is one of the common electrolyte imbalances among hospitalized patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) being a common etiology for hyponatremia. There are multiple pathophysiologic considerations in the differential diagnosis of the etiologic factor for SIADH, including infections such as pneumonia and meningitis, as well as coronavirus disease 2019 (COVID-19) infection. However, SIADH, as the sole initial presentation of the infection of COVID-19, is rarely reported. In this report, we present a case of SIADH as the initial and only presentation of a COVID-19 infection, highlighting the clinical course and treatment strategy while providing the putative pathophysiologic insights into this unusual and potentially serious complication of COVID-19 infection.
低钠血症是住院患者常见的电解质紊乱之一，抗利尿激素分泌不当综合征（SIADH）是低钠血症的常见病因。SIADH病因的鉴别诊断存在多种病理生理学考量因素，包括肺炎和脑膜炎等感染，以及2019冠状病毒病（COVID-19）感染。然而，SIADH作为COVID-19感染的唯一初始表现鲜有报道。在本报告中，我们呈现了一例以SIADH作为COVID-19感染初始且唯一表现的病例，重点介绍了临床病程和治疗策略，同时对这种COVID-19感染的不寻常且可能严重的并发症提供了假定的病理生理学见解。
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