孕早期天冬氨酸转氨酶/血小板比率指数评分能否预测妊娠期肝内胆汁淤积症？
Can first-trimester aspartate aminotransferase/platelet ratio index score predict intrahepatic cholestasis of pregnancy?
作者信息
Gok Koray, Takmaz Taha, Kose Osman, Tuten Nevin, Acikgoz Abdullah Serdar, Bostanci Mehmet Suhha, Ozden Selcuk
机构信息
Department of Obstetrics and Gynecology, Sakarya University School of Medicine, Sakarya, Turkiye.
Department of Obstetrics and Gynecology, Bezmialem University School of Medicine, Istanbul, Turkiye.
出版信息
Hepatol Forum. 2023 Jan 17;4(1):30-34. doi: 10.14744/hf.2022.2022.0031. eCollection 2023 Jan.
BACKGROUND AND AIM
The study aimed to investigate the effectiveness of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet values in predicting intrahepatic cholestasis of pregnancy (ICP) in the first trimester, together with the aspartate aminotransferase/platelet ratio index (APRI) score.
MATERIALS AND METHODS
This study consisted of a patient group diagnosed with ICP (n=49) and a control group (n=62). Laboratory tests of both groups were analyzed retrospectively.
RESULTS
The first-trimester APRI score and AST and ALT values were found to be statistically significantly higher than those of the control group. The platelet value was found to be statistically significantly lower in the study group, even though it was within the normal reference range.
CONCLUSION
The first-trimester APRI score was found to be effective in predicting ICP. In addition, the first-trimester AST, ALT, and platelet values were found to be effective in predicting ICP diagnosed in the third trimester even though if not as much as the APRI score.
背景与目的
本研究旨在探讨天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和血小板值，以及天冬氨酸氨基转移酶/血小板比值指数（APRI）评分在孕早期预测妊娠肝内胆汁淤积症（ICP）的有效性。
材料与方法
本研究包括一个诊断为ICP的患者组（n = 49）和一个对照组（n = 62）。对两组的实验室检查进行回顾性分析。
结果
发现孕早期APRI评分以及AST和ALT值在统计学上显著高于对照组。研究组的血小板值虽在正常参考范围内，但在统计学上显著低于对照组。
结论
发现孕早期APRI评分在预测ICP方面有效。此外，发现孕早期AST、ALT和血小板值在预测孕晚期诊断出的ICP方面有效，尽管不如APRI评分有效。
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