Cemortan Maria, Iliadi-Tulbure Corina, Sagaidac Irina, Cernetchi Olga
Department of Obstetrics and Gynecology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
AJOG Glob Rep. 2024 Mar 10;4(2):100337. doi: 10.1016/j.xagr.2024.100337. eCollection 2024 May.
Intrahepatic cholestasis of pregnancy is a pregnancy-related liver condition that is characterized by elevated liver function tests and/or bile acids in the presence of pruritis.
The study aimed to assess the aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index scores in intrahepatic cholestasis of pregnancy.
The prospective study was carried out by assessing 142 women: 71 whose pregnancies were complicated by intrahepatic cholestasis of pregnancy and 71 without intrahepatic cholestasis of pregnancy. The Fibrosis-4 Index score and aspartate aminotransferase to Platelet Ratio Index were assessed.
Our findings indicate that both aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index scores were reliable indicators of intrahepatic cholestasis of pregnancy, correlating with important complications of the condition.
This study provides valuable information to help clinicians better diagnose and perform the management of intrahepatic cholestasis of pregnancy.
妊娠期肝内胆汁淤积症是一种与妊娠相关的肝脏疾病,其特征是在出现瘙痒的情况下肝功能检查和/或胆汁酸升高。
本研究旨在评估妊娠期肝内胆汁淤积症患者的天冬氨酸转氨酶与血小板比值指数(APRI)和纤维化-4指数(FIB-4)评分。
本前瞻性研究通过评估142名女性进行:71名妊娠合并妊娠期肝内胆汁淤积症的女性和71名未患妊娠期肝内胆汁淤积症的女性。评估了纤维化-4指数评分和天冬氨酸转氨酶与血小板比值指数。
我们的研究结果表明,天冬氨酸转氨酶与血小板比值指数和纤维化-4指数评分都是妊娠期肝内胆汁淤积症的可靠指标,与该疾病的重要并发症相关。
本研究提供了有价值的信息,以帮助临床医生更好地诊断和管理妊娠期肝内胆汁淤积症。