头孢曲松对胆红素 - 白蛋白结合的影响。
Ceftriaxone effect on bilirubin-albumin binding.
作者信息
Fink S, Karp W, Robertson A
机构信息
Department of Pediatrics, Medical College of Georgia, Augusta 30912.
出版信息
Pediatrics. 1987 Dec;80(6):873-5.
The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 X 10(4) L/mol. Therapeutic levels of ceftriaxone decrease the reserve albumin concentration in newborn serum by 39%. These results indicate that ceftriaxone may increase the risk of bilirubin encephalopathy in jaundiced premature infants.
采用过氧化物酶法结合人血清白蛋白以及透析速率法结合成人和新生儿血清，在体外测定头孢曲松对胆红素 - 白蛋白结合的影响。头孢曲松与胆红素竞争与人血清白蛋白的结合；置换常数为1.5×10⁴ L/mol。治疗水平的头孢曲松可使新生儿血清中的储备白蛋白浓度降低39%。这些结果表明，头孢曲松可能会增加黄疸早产儿发生胆红素脑病的风险。
Zotero 插件