Marhaeni Wulandewi, Felicia Fabiola Vania, Sumadi Jap Arvin Leonard, Hartoyo Edi, Andayani Pudji
Division of Hematology and Oncology, Department of Pediatrics of Ulin General Hospital, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia.
Department of Pediatrics of Ulin General Hospital, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia.
Front Med (Lausanne). 2023 Feb 9;10:1056599. doi: 10.3389/fmed.2023.1056599. eCollection 2023.
Ferritin has been recognized as a predictor of severity among Coronavirus-19 disease (COVID-19) patients. Studies have shown higher levels of ferritin in patients with COVID-19 than in healthy children. Patients with transfusion-dependent thalassemia (TDT) basically have high ferritin level due to iron overload. It is uncertain whether serum ferritin level in these patients is associated with COVID-19 infection.
To evaluate ferritin levels in TDT with COVID-19 before, during, and after the course of infection.
This retrospective study enrolled all TDT children with COVID-19 infection that were hospitalized in Ulin General Hospital Banjarmasin during the COVID-19 pandemic (March 2020 to June 2022). Data were collected from medical records.
There were 14 patients included in this study, 5 patients had mild symptoms and 9 patients were asymptomatic. The mean of hemoglobin level upon admission was 8.1 ± 3 g/dL and serum ferritin level were 5148.5 ± 2651.8 ng/mL. The average serum ferritin level during COVID-19 infection was 2373.2 ng/mL higher than before infection and then decreased by 952.4 ng/mL after infection. We found no association of increasing serum ferritin with patients' symptoms ( = 0.27). The severity of anemia also was not correlated with the presentation of COVID-19 infection ( = 0.902).
Serum ferritin levels in TDT children may not reflect disease severity or predict poor outcomes during COVID-19 infection. However, the presence of other co-morbid conditions/confounders warrants cautious interpretation.
铁蛋白已被公认为是冠状病毒病（COVID-19）患者病情严重程度的预测指标。研究表明，COVID-19患者的铁蛋白水平高于健康儿童。依赖输血的地中海贫血（TDT）患者由于铁过载，铁蛋白水平基本较高。尚不确定这些患者的血清铁蛋白水平是否与COVID-19感染有关。
评估TDT合并COVID-19患者在感染前、感染期间和感染后的铁蛋白水平。
这项回顾性研究纳入了COVID-19大流行期间（2020年3月至2022年6月）在班贾尔马辛乌林综合医院住院的所有TDT合并COVID-19感染的儿童。数据从病历中收集。
本研究共纳入14例患者，其中5例有轻度症状，9例无症状。入院时血红蛋白水平的平均值为8.1±3 g/dL，血清铁蛋白水平为5148.5±2651.8 ng/mL。COVID-19感染期间血清铁蛋白平均水平比感染前高2373.2 ng/mL，感染后下降了952.4 ng/mL。我们发现血清铁蛋白升高与患者症状无关（P = 0.27）。贫血的严重程度也与COVID-19感染的表现无关（P = 0.902）。
TDT儿童的血清铁蛋白水平可能无法反映COVID-19感染期间的疾病严重程度或预测不良预后。然而，其他合并症/混杂因素的存在需要谨慎解读。
