Gater Deborah L, Hughes Keontré I, Stojanoff Vivian, Isakovic Abdel F
University College London, London WC1E 6BT, U.K.
Colgate University, Hamilton, New York 13346-1338, United States.
ACS Omega. 2023 Feb 8;8(7):6225-6233. doi: 10.1021/acsomega.2c04914. eCollection 2023 Feb 21.
Pseudo-ternary mixtures of lamellar phase phospholipids (DPPC and brain sphingomyelin with cholesterol) were studied below while comparing the influence of cholesterol content, temperature, and the presence of small quantities of vitamin D binding protein (DBP) or vitamin D receptor (VDR). The measurements, conducted by X-ray diffraction (XRD) and nuclear magnetic resonance (NMR), cover a range of cholesterol concentrations (20% mol. wt to 40% mol. wt.) and physiologically relevant temperature range (294-314 K). In addition to rich intraphase behavior, data and modeling are used to approximate the lipids' headgroup location variations under the abovementioned experimental conditions.
在比较胆固醇含量、温度以及少量维生素D结合蛋白（DBP）或维生素D受体（VDR）的存在所产生的影响时，研究了层状相磷脂（二棕榈酰磷脂酰胆碱和脑鞘磷脂与胆固醇）的伪三元混合物在低于[此处原文缺失具体数值]时的情况。通过X射线衍射（XRD）和核磁共振（NMR）进行的测量涵盖了一系列胆固醇浓度（20%摩尔重量至40%摩尔重量）和生理相关温度范围（294 - 314 K）。除了丰富的相内行为外，数据和建模还用于估算上述实验条件下脂质头部基团位置的变化。
