Suppr超能文献

老年患者回肠储袋肛管吻合术:术后结果及储袋炎治疗综述

Ileal Pouch-Anal Anastomosis in the Older Adult: a Review of Postoperative Outcomes and Pouchitis Treatment.

作者信息

Chen Sabrina L, Faye Adam S, Chang Shannon

机构信息

Department of Gastroenterology, New York University Grossman School of Medicine, 305 East 33rd Street, NY 10016 New York, USA.

出版信息

Curr Treat Options Gastroenterol. 2022 Dec;20(4):564-581. doi: 10.1007/s11938-022-00405-x. Epub 2022 Dec 6.

Abstract

PURPOSE OF REVIEW

Ileal pouch-anal anastomosis (IPAA) has become the preferred surgical treatment for patients with medically refractive ulcerative colitis (UC). Previous studies have suggested that outcomes of this procedure may be worse in older patients; however, more recent reports have suggested that IPAA in select patients is safe, feasible, and results in good quality of life. In this review, we discuss the recent literature surrounding clinical considerations and treatment management of IPAA in older adults.

RECENT FINDINGS

IPAA complication rates and adverse events are similar in the older adult population, as compared to the younger adult patient population. Although fecal urgency and incontinence may be more common among older adults, chronological age alone is not a contraindication for IPAA surgery, as good quality of life can still be achieved. In this review, we will also discuss the development of pouchitis after IPAA, particularly among older adults, as the emergence of newer biologic drugs has shifted the treatment landscape.

SUMMARY

IPAA can be a safe and effective treatment modality for older adults with UC, with high self-reported patient satisfaction. Patient optimization and careful case selection are vital to achieving these outcomes, and specialized preoperative assessments and counseling can help facilitate the proper treatment.

摘要

综述目的

回肠储袋肛管吻合术(IPAA)已成为药物治疗无效的溃疡性结肠炎(UC)患者的首选手术治疗方法。既往研究提示,该手术在老年患者中的结局可能较差;然而,最近的报告表明,特定患者行IPAA是安全、可行的,且能带来良好的生活质量。在本综述中,我们讨论了围绕老年人IPAA临床考虑和治疗管理的最新文献。

最新发现

与年轻成年患者相比,老年人群中IPAA的并发症发生率和不良事件相似。虽然便急和大便失禁在老年人中可能更常见,但仅按年龄顺序并非IPAA手术的禁忌证,因为仍可实现良好的生活质量。在本综述中,我们还将讨论IPAA术后袋炎的发生情况,尤其是在老年人中,因为新型生物药物的出现改变了治疗格局。

总结

IPAA对于老年UC患者可能是一种安全有效的治疗方式,患者自我报告的满意度较高。患者优化和仔细的病例选择对于实现这些结局至关重要,专门的术前评估和咨询有助于促进恰当的治疗。

相似文献

1
Ileal Pouch-Anal Anastomosis in the Older Adult: a Review of Postoperative Outcomes and Pouchitis Treatment.
Curr Treat Options Gastroenterol. 2022 Dec;20(4):564-581. doi: 10.1007/s11938-022-00405-x. Epub 2022 Dec 6.
2
Outcomes and Management of the Ileal Pouch-Anal Anastomosis in the Elderly.
Curr Treat Options Gastroenterol. 2018 Sep;16(3):275-288. doi: 10.1007/s11938-018-0184-0.
4
Outcomes after ileal pouch anal anastomosis in patients with primary sclerosing cholangitis.
J Crohns Colitis. 2014 Jul;8(7):662-70. doi: 10.1016/j.crohns.2013.12.007. Epub 2014 Jan 11.
5
Functional outcomes following ileal pouch-anal anastomosis (IPAA) in older patients: a systematic review.
Int J Colorectal Dis. 2016 Mar;31(3):481-92. doi: 10.1007/s00384-015-2475-4. Epub 2016 Jan 12.
8
Transanal ileal pouch anal anastomosis for ulcerative colitis in children and adults: a systematic review and meta-analysis.
Pediatr Surg Int. 2022 Dec;38(12):1671-1680. doi: 10.1007/s00383-022-05222-y. Epub 2022 Sep 17.
10
Relationship Between Stages of Ileal Pouch-Anal Anastomosis, Timing of Restoration of Fecal Continuity, and Pouchitis.
Dig Dis Sci. 2022 Nov;67(11):5220-5226. doi: 10.1007/s10620-022-07440-9. Epub 2022 Mar 5.

引用本文的文献

1
Personalized Approach to Chronic Antibiotic-Refractory Pouchitis: A Case Report and Review of the Literature.
Cureus. 2024 Feb 1;16(2):e53398. doi: 10.7759/cureus.53398. eCollection 2024 Feb.

本文引用的文献

2
3
Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.
N Engl J Med. 2022 Jan 27;386(4):316-326. doi: 10.1056/NEJMoa2109927.
4
Safety and Efficacy of Anti-TNF Therapy in Older Adults With Ulcerative Colitis: A New Path Forward.
Gastroenterology. 2022 May;162(6):1762-1764. doi: 10.1053/j.gastro.2021.12.003. Epub 2021 Dec 2.
7
Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium.
Lancet Gastroenterol Hepatol. 2021 Oct;6(10):826-849. doi: 10.1016/S2468-1253(21)00101-1. Epub 2021 Aug 18.
8
Efficacy of Vedolizumab in a Nationwide Cohort of Elderly Inflammatory Bowel Disease Patients.
Inflamm Bowel Dis. 2022 May 4;28(5):734-744. doi: 10.1093/ibd/izab163.
9
Sacral nerve stimulation in patients with ileal pouch-anal anastomosis.
Int J Colorectal Dis. 2021 Sep;36(9):1937-1943. doi: 10.1007/s00384-021-03981-z. Epub 2021 Jun 23.
10
Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis.
Colorectal Dis. 2021 Sep;23(9):2416-2424. doi: 10.1111/codi.15772. Epub 2021 Jul 16.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验