Chen Sabrina L, Faye Adam S, Chang Shannon
Department of Gastroenterology, New York University Grossman School of Medicine, 305 East 33rd Street, NY 10016 New York, USA.
Curr Treat Options Gastroenterol. 2022 Dec;20(4):564-581. doi: 10.1007/s11938-022-00405-x. Epub 2022 Dec 6.
Ileal pouch-anal anastomosis (IPAA) has become the preferred surgical treatment for patients with medically refractive ulcerative colitis (UC). Previous studies have suggested that outcomes of this procedure may be worse in older patients; however, more recent reports have suggested that IPAA in select patients is safe, feasible, and results in good quality of life. In this review, we discuss the recent literature surrounding clinical considerations and treatment management of IPAA in older adults.
IPAA complication rates and adverse events are similar in the older adult population, as compared to the younger adult patient population. Although fecal urgency and incontinence may be more common among older adults, chronological age alone is not a contraindication for IPAA surgery, as good quality of life can still be achieved. In this review, we will also discuss the development of pouchitis after IPAA, particularly among older adults, as the emergence of newer biologic drugs has shifted the treatment landscape.
IPAA can be a safe and effective treatment modality for older adults with UC, with high self-reported patient satisfaction. Patient optimization and careful case selection are vital to achieving these outcomes, and specialized preoperative assessments and counseling can help facilitate the proper treatment.
回肠储袋肛管吻合术(IPAA)已成为药物治疗无效的溃疡性结肠炎(UC)患者的首选手术治疗方法。既往研究提示,该手术在老年患者中的结局可能较差;然而,最近的报告表明,特定患者行IPAA是安全、可行的,且能带来良好的生活质量。在本综述中,我们讨论了围绕老年人IPAA临床考虑和治疗管理的最新文献。
与年轻成年患者相比,老年人群中IPAA的并发症发生率和不良事件相似。虽然便急和大便失禁在老年人中可能更常见,但仅按年龄顺序并非IPAA手术的禁忌证,因为仍可实现良好的生活质量。在本综述中,我们还将讨论IPAA术后袋炎的发生情况,尤其是在老年人中,因为新型生物药物的出现改变了治疗格局。
IPAA对于老年UC患者可能是一种安全有效的治疗方式,患者自我报告的满意度较高。患者优化和仔细的病例选择对于实现这些结局至关重要,专门的术前评估和咨询有助于促进恰当的治疗。