自体保存的冷冻羊膜导致的微生物性角膜炎

Microbial Keratitis following Self-Retained Cryopreserved Amniotic Membrane.

作者信息

Fairaq Rafah, AlBalawi Eman D, Al-Swailem Samar A

机构信息

aAnterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

bDepartment of Ophthalmology, University of Jeddah, Jeddah, Saudi Arabia.

出版信息

Case Rep Ophthalmol. 2022 Sep 30;13(3):724-729. doi: 10.1159/000525659. eCollection 2022 Sep-Dec.

DOI:10.1159/000525659

PMID:36845448

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9944211/

Abstract

The aim of this study was to report a severe case of mixed fungal and bacterial microbial keratitis following implantation of a self-retained cryopreserved amniotic membrane, PROKERA® SLIM (Bio-Tissue, Inc) in a patient with history of neurotrophic ulcer secondary to herpetic epithelial keratitis. Despite maximally tolerated topical and systemic therapy, the patient's eye continued to deteriorate and eventually required evisceration. PROKERA implantation might be associated with severe recalcitrant microbial keratitis. Caution is urged when considering implantation especially in monocular patients.

摘要

本研究的目的是报告一例在植入自固定冷冻保存羊膜（PROKERA® SLIM，Bio-Tissue公司）后发生的严重混合真菌和细菌感染性角膜溃疡病例，该患者有疱疹性上皮性角膜炎继发神经营养性溃疡病史。尽管给予了最大耐受量的局部和全身治疗，患者的眼睛仍持续恶化，最终需要行眼球摘除术。PROKERA植入可能与严重的顽固性微生物性角膜炎有关。在考虑植入时应谨慎，尤其是在单眼患者中。