并发华氏巨球蛋白血症和突变型转甲状腺素蛋白心脏淀粉样变性
Concurrent Waldenstrom Macroglobulinemia and Mutant Transthyretin Cardiac Amyloidosis.
作者信息
Qian Xiaoxiao, Bakhshi Hooman, Biswas Rakesh, Gattani Raghav, Kennedy Jamie L
机构信息
Departemt of Cardiology, Inova Heart and Vascular Institute, Falls Church, VA, USA.
Departemt of Hematology and Oncology, Inova Fairfax Hospital, Falls Church, VA, USA.
出版信息
J Community Hosp Intern Med Perspect. 2022 Nov 7;12(6):95-99. doi: 10.55729/2000-9666.1117. eCollection 2022.
Cardiac amyloidosis is caused by abnormal deposit of amyloid in the myocardium and can be divided into light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis. ATTR amyloidosis can be further divided into wild-type and mutant type based on genetic mutation. Differentiation between AL, wild-type, and mutant type ATTR amyloidosis has significant prognostic and therapeutic implications.
心脏淀粉样变性是由淀粉样蛋白在心肌中的异常沉积引起的，可分为轻链（AL）淀粉样变性和转甲状腺素蛋白（ATTR）淀粉样变性。ATTR淀粉样变性可根据基因突变进一步分为野生型和突变型。区分AL、野生型和突变型ATTR淀粉样变性具有重要的预后和治疗意义。
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