Cai Huazhong, Ren Yongfei, Chen Shuangwei, Wang Yue, Chu Liangmei
Department of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Radiation Oncology, Institute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Front Oncol. 2023 Feb 8;13:1119369. doi: 10.3389/fonc.2023.1119369. eCollection 2023.
Low response rate and treatment resistance are frequent problems in the immunotherapy of tumors, resulting in the unsatisfactory therapeutic effects. Ferroptosis is a form of cell death characterized by the accumulation of lipid peroxides. In recent years, it has been found that ferroptosis may be related to the treatment of cancer. Various immune cells (including macrophages and CD8 T cells) can induce ferroptosis of tumor cells, and synergistically enhance the anti-tumor immune effects. However, the mechanisms are different for each cell types. DAMP released by cancer cells undergoing ferroptosis lead to the maturation of dendritic cells, cross-induction of CD8 T cells, IFN-γ production and M1 macrophage production. Thus, it activates the adaptability of the tumor microenvironment and forms positive feedback of the immune response. It suggests that induction of ferroptosis may contribute to reducing resistance of cancer immunotherapy and has great potential in cancer therapy. Further research into the link between ferroptosis and tumor immunotherapy may offer hope for those cancers that are difficult to treat. In this review, we focus on the role of ferroptosis in tumor immunotherapy, explore the role of ferroptosis in various immune cells, and discuss potential applications of ferroptosis in tumor immunotherapy.
低反应率和治疗抗性是肿瘤免疫治疗中常见的问题，导致治疗效果不尽人意。铁死亡是一种以脂质过氧化物积累为特征的细胞死亡形式。近年来，人们发现铁死亡可能与癌症治疗有关。各种免疫细胞（包括巨噬细胞和CD8 T细胞）可诱导肿瘤细胞发生铁死亡，并协同增强抗肿瘤免疫效应。然而，每种细胞类型的机制各不相同。发生铁死亡的癌细胞释放的损伤相关分子模式可导致树突状细胞成熟、CD8 T细胞交叉诱导、产生干扰素-γ和M1巨噬细胞。因此，它激活了肿瘤微环境的适应性并形成免疫反应的正反馈。这表明诱导铁死亡可能有助于降低癌症免疫治疗的抗性，在癌症治疗中具有巨大潜力。进一步研究铁死亡与肿瘤免疫治疗之间的联系可能为那些难以治疗的癌症带来希望。在这篇综述中，我们重点关注铁死亡在肿瘤免疫治疗中的作用，探讨铁死亡在各种免疫细胞中的作用，并讨论铁死亡在肿瘤免疫治疗中的潜在应用。
