Land Thomas, Silva Dulanka, Paluzzi Alessandro, Tsermoulas Georgios, Ahmed Shahzada
Department of Neurosurgery and Skull Base Surgery Queen Elizabeth University Hospital Birmingham Birmingham UK.
Department of ENT Skull Base Surgery Queen Elizabeth University Hospital Birmingham Birmingham UK.
Laryngoscope Investig Otolaryngol. 2022 Dec 30;8(1):55-62. doi: 10.1002/lio2.1000. eCollection 2023 Feb.
Expanded endonasal approaches (EEAs) to the skull base have increased the scope and extent of pathologies that can be treated endoscopically. The trade-off is creation of large skull base bone defects requiring reconstruction to re-establish barriers between the sino-nasal mucosa and subarachnoid space to prevent CSF leak and infection. A popular reconstructive technique is the local vascularized pedicled naso-septal flap, an option that may not always be possible when there is disruption of the vascular pedicle from multiple previous surgeries, adjuvant radiotherapy or extensive tumor infiltration. An alternative is the regional temporo-parietal fascial flap (TPFF) transposed via the trans-pterygoid route. We implemented a modification of this technique incorporating contralateral temporalis muscle at the tip of this flap and deeper vascularised pericranial layers within the pedicle to provide a more robust flap in selected cases.
STUDY DESIGN/METHODS: A retrospective review of two cases is presented with both patients having undergone multiple EEAs to resect skull base tumors with adjuvant radiotherapy, their postoperative courses complicated by recalcitrant CSF leaks resistant to multiple surgeries.
Our patients had their persistent CSF fistulae repaired using infra-temporal transposition of the TPFF modified to include some of the contralateral temporalis muscle with optimisation of a vascular pedicle: a temporo-parietal temporalis myo-fascial flap (TPTMFF). Both CSF leaks resolved without further complication.
In situations where local flap repair to reconstruct skull-base defects following EEA may not be viable or has failed, a modified regional flap incorporating temporo-parietal fascia with a preserved vascular pedicle along with attached temporalis muscle plug may provide a robust alternative option.
扩大经鼻入路至颅底增加了可在内镜下治疗的病变范围。权衡之处在于会造成大的颅底骨缺损,需要进行重建以重新建立鼻窦黏膜与蛛网膜下腔之间的屏障,防止脑脊液漏和感染。一种常用的重建技术是带血管蒂的鼻中隔局部皮瓣,但当血管蒂因多次既往手术、辅助放疗或广泛肿瘤浸润而中断时,这种选择可能并不总是可行。另一种选择是通过翼突途径转移的颞顶筋膜瓣(TPFF)。我们对该技术进行了改良,在皮瓣尖端加入对侧颞肌,并在蒂内加入更深层的血管化颅骨膜层,以便在特定病例中提供更强大的皮瓣。
研究设计/方法:回顾性分析两例患者,这两名患者均接受了多次扩大经鼻入路切除颅底肿瘤并辅助放疗,术后病程因多次手术仍顽固不愈的脑脊液漏而复杂化。
我们的患者使用改良的TPFF经颞下转移修复持续性脑脊液瘘,改良包括加入部分对侧颞肌并优化血管蒂,即颞顶颞肌肌筋膜瓣(TPTMFF)。脑脊液漏均得以解决,无进一步并发症。
在扩大经鼻入路后局部皮瓣修复重建颅底缺损不可行或失败的情况下,一种改良的区域皮瓣,包括保留血管蒂的颞顶筋膜以及附着的颞肌瓣,可能提供一种可靠的替代选择。