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眼葡萄膜炎,一种佐莱膦酸辅助治疗早期乳腺癌的罕见但重要的并发症。

Uveitis, a rare but important complication of adjuvant zoledronic acid for early-stage breast cancer.

机构信息

Rutgers Robert Wood Johnson Medical School, Department of Medicine.

Rutgers Cancer Institute of New Jersey, Department of Surgery.

出版信息

Anticancer Drugs. 2023 Apr 1;34(4):592-594. doi: 10.1097/CAD.0000000000001503. Epub 2023 Feb 24.

Abstract

Bisphosphonates such as zoledronic acid are an important part of adjuvant therapy to reduce the risk of recurrence in early-stage breast cancer. Uveitis remains one of the lesser-known side effects of zoledronic acid; prompt recognition is essential to ensure patients receive appropriate and timely care to help prevent permanent vision loss. We report a case of anterior uveitis in a postmenopausal woman who presented with visual symptoms after receiving the first dose of zoledronic acid. This case report serves to educate and increase awareness of the risk of uveitis in patients who are given zoledronic acid. This is the first and only reported case of zoledronic acid when used in the adjuvant setting for the treatment of breast cancer.

摘要

双膦酸盐类药物如唑来膦酸是辅助治疗的重要组成部分,可降低早期乳腺癌复发的风险。葡萄膜炎仍然是唑来膦酸不太为人知的副作用之一;及时识别至关重要,以确保患者得到适当和及时的治疗,帮助预防永久性视力丧失。我们报告了一例绝经后妇女在接受唑来膦酸首剂量后出现视觉症状的前葡萄膜炎病例。本病例报告旨在教育并提高对接受唑来膦酸治疗的患者发生葡萄膜炎风险的认识。这是首例也是唯一报告的唑来膦酸在辅助治疗乳腺癌中的应用。

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