Zhao Jinlu, Li Guodong, Ren Yi, Zhang Zhicheng, Chen Hongsheng, Zhang Haopeng, Zhao Xingyu, Li Wang, Jia Yucheng, Guan Xue, Liu Ming
Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Anticancer Drugs. 2023 Nov 1;34(10):1112-1121. doi: 10.1097/CAD.0000000000001513. Epub 2023 Mar 24.
The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated anticancer effects using the human colon cancer HCT-116 cell line. After 72 h of ellagic acid treatment, a total of 206 long noncoding RNAs (lncRNAs) with differential expression greater than 1.5-fold were identified (115 down-regulated and 91 up-regulated). Furthermore, the co-expression network analysis of differentially expressed lncRNA and mRNA showed that differential expressed lncRNA might be the target of ellagic acid activity in inhibiting CRC.
天然酚类化合物鞣花酸具有抗癌作用，包括对结直肠癌（CRC）的活性。此前，我们报道鞣花酸可抑制CRC的增殖，并可诱导细胞周期停滞和凋亡。本研究使用人结肠癌HCT-116细胞系研究了鞣花酸介导的抗癌作用。鞣花酸处理72小时后，共鉴定出206个差异表达大于1.5倍的长链非编码RNA（lncRNA）（115个下调，91个上调）。此外，差异表达lncRNA和mRNA的共表达网络分析表明，差异表达lncRNA可能是鞣花酸抑制CRC活性的靶点。
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