Caprini Elisabetta, D'Agnese Giampaolo, Brennan Peter A, Rahimi Siavash
Anatomia Patologica, Istituto Dermopatico dell'Immacolata IRCCS, Rome, Italy.
Information Technology, Istituto Dermopatico dell'immacolata IDI-IRCCS, Rome, Italy.
J Oral Pathol Med. 2023 Apr;52(4):300-304. doi: 10.1111/jop.13419. Epub 2023 Mar 13.
The increase of the incidence of human papillomavirus dependent oropharyngeal squamous cell carcinoma is alarming, although we have greatly progressed in the classification and staging of this disease. We now know that human papillomavirus related oropharyngeal squamous cell carcinoma is a sub-type of head and neck squamous cell carcinoma with favourable prognosis and good response to therapy that needs a proper system of classification and staging. Thus, in routine practice it is essential to test patients for the presence of human papillomavirus. The most popular technique to assess human papillomavirus status is immunohistochemistry on biopsy samples with p16, which is an excellent surrogate for high-risk human papillomavirus infection. Another highly sensitive and specific tissue-based technique for the detection of human papillomavirus is RNAscope In situ hybridization that has a prohibitive cost, limiting its use in routine practice. Radiomics is an artificial intelligence based non-invasive method of computational analysis of computed tomography, magnetic resonance imaging, positron emission tomography, and ultrasound images.
In this review, we summarise the last findings of radiomics applied to human papillomavirus associated oropharyngeal squamous cell carcinoma.
A growing body of evidence suggest that radiomics is able to characterise and detect early relapse after treatment, and enable development of tailored therapy of human papillomavirus positive oropharyngeal squamous cell carcinoma.
人乳头瘤病毒相关口咽鳞状细胞癌的发病率不断上升，令人担忧，尽管我们在该疾病的分类和分期方面已取得了很大进展。我们现在知道，人乳头瘤病毒相关口咽鳞状细胞癌是头颈部鳞状细胞癌的一种亚型，预后良好，对治疗反应良好，需要一个合适的分类和分期系统。因此，在常规实践中，对患者进行人乳头瘤病毒检测至关重要。评估人乳头瘤病毒状态最常用的技术是对活检样本进行p16免疫组织化学检测，p16是高危人乳头瘤病毒感染的极佳替代指标。另一种用于检测人乳头瘤病毒的高度敏感且特异的基于组织的技术是RNAscope原位杂交，但该技术成本高昂，限制了其在常规实践中的应用。放射组学是一种基于人工智能的对计算机断层扫描、磁共振成像、正电子发射断层扫描和超声图像进行计算分析的非侵入性方法。
在本综述中，我们总结了放射组学应用于人乳头瘤病毒相关口咽鳞状细胞癌的最新研究结果。
越来越多的证据表明，放射组学能够对治疗后的早期复发进行特征描述和检测，并有助于制定人乳头瘤病毒阳性口咽鳞状细胞癌的个性化治疗方案。
