*Gastroenterology.
Pathology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Surg Laparosc Endosc Percutan Tech. 2023 Apr 1;33(2):108-114. doi: 10.1097/SLE.0000000000001152.
Colorectal cancer primarily arises from colorectal polyps. Early screening and removal is beneficial, especially in asymptomatic populations. This research aimed to reveal the risk factors detected in medical check-ups for colorectal polyps in asymptomatic people.
Clinical data of 933 asymptomatic people who underwent colonoscopies from May 2014 to December 2021 was analyzed retrospectively. Data included sex, age, colonoscopy findings, polyp pathology, polyp number, and blood test results. The distribution of colorectal lesions was analyzed. Participants were divided into control and polyp groups, adenomatous and non-adenomatous polyp groups, and single and multiple adenoma groups.
Participants' age, proportion of males, carcinoembryonic antigen (CEA), uric acid and glycosylated hemoglobin levels were significantly higher ( P ≤0.05) in the polyp group. Age (>40 y), sex (male), and CEA level (>1.435 ng/mL) were independent risk factors for polyps. CEA, uric acid, carbohydrate antigen 19-9, triglyceride, and total cholesterol levels were significantly higher ( P <0.05) in the adenoma group than in the non-adenomatous group. CEA level (>1.435 ng/mL) was an independent predictor for adenomas ( P <0.05). Participants' age, proportion of males, CEA, glycosylated hemoglobin, and fasting blood glucose levels were significantly higher ( P <0.05) in the multiple adenoma group than in the single group; the high-density lipoprotein cholesterol level was lower ( P <0.05). No independent risk factors were found for the number of adenomas.
Serum CEA level (>1.435 ng/mL) was independent risk factor for colorectal polyps. It may be conducive to improve discriminative ability of colorectal cancer risk stratification model.
结直肠癌主要源于结直肠息肉。早期筛查和切除是有益的，尤其是在无症状人群中。本研究旨在揭示无症状人群接受医学检查时发现的结直肠息肉的危险因素。
回顾性分析 2014 年 5 月至 2021 年 12 月期间 933 名接受结肠镜检查的无症状人群的临床资料。资料包括性别、年龄、结肠镜检查结果、息肉病理、息肉数量和血液检查结果。分析结直肠病变的分布。将参与者分为对照组和息肉组、腺瘤性和非腺瘤性息肉组、单发和多发腺瘤组。
息肉组的年龄、男性比例、癌胚抗原（CEA）、尿酸和糖化血红蛋白水平显著较高（P≤0.05）。年龄（>40 岁）、性别（男性）和 CEA 水平（>1.435ng/ml）是息肉的独立危险因素。CEA、尿酸、糖类抗原 19-9、三酰甘油和总胆固醇水平在腺瘤组显著较高（P<0.05）。CEA 水平（>1.435ng/ml）是腺瘤的独立预测因子（P<0.05）。多发性腺瘤组的年龄、男性比例、CEA、糖化血红蛋白和空腹血糖水平显著较高（P<0.05），高密度脂蛋白胆固醇水平较低（P<0.05）。多发性腺瘤数量无独立危险因素。
血清 CEA 水平（>1.435ng/ml）是结直肠息肉的独立危险因素。可能有助于提高结直肠癌风险分层模型的鉴别能力。
