Yao Chunmeng, Ou Juanjuan, Zhou Liping, Liu Junlan
Department of Nephrology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.
Department of Nephrology, Lichuan People's Hospital, Lichuan, Hubei, China.
Scand J Clin Lab Invest. 2023 Apr;83(2):119-124. doi: 10.1080/00365513.2023.2180659. Epub 2023 Feb 27.
Omentin-1 shows a critical protective role of cardiovascular events in chronic kidney disease. This study aimed to further assess serum omentin-1 level and its relationship with clinical features and accumulating major adverse cardiac/cerebral events (MACCE) risk in end-stage renal disease patients undergoing continuous ambulatory peritoneal dialysis (CAPD-ESRD). Totally, 290 CAPD-ESRD patients and 50 healthy controls (HCs) were recruited, and their serum omentin-1 levels were measured by enzyme-linked immunosorbent assay. All CAPD-ESRD patients were followed up for 36 months to assess accumulating MACCE rate. Omentin-1 level in CAPD-ESRD patients was lower than that in HCs [median (interquartile range): 229.350 (153.575-355.550) vs. 449.800 (354.125-527.450) pg/mL] ( < 0.001). Moreover, omentin-1 level was inversely related to C-reactive protein (CRP) ( = 0.028), total cholesterol ( = 0.023), and low-density lipoprotein cholesterol ( = 0.005), while there was no correlation in omentin-1 level with other clinical features in CAPD-ESRD patients. The accumulating MACCE rate was 4.5%, 13.1%, and 15.5% in the first, second, and third years respectively, and it was lower in CAPD-ESRD patients with high level of omentin-1 than those with low level of omentin-1 ( = 0.004). Furthermore, omentin-1 (hazard ratio (HR)=0.422, = 0.013) and high-density lipoprotein cholesterol (HR = 0.396, = 0.010) were independently associated with reduced accumulating MACCE rate; while age (HR = 3.034, = 0.006), peritoneal dialysis duration (HR = 2.741, = 0.006), CRP (HR = 2.289, = 0.026), serum uric acid (HR = 2.538, = 0.008) were independently related to higher accumulating MACCE rate in CAPD-ESRD patients. In conclusion, serum high omentin-1 level is associated with decreased inflammation, lipid levels, and accumulating MACCE risk in CAPD-ESRD patients.
网膜素-1在慢性肾脏病的心血管事件中发挥着关键的保护作用。本研究旨在进一步评估持续性非卧床腹膜透析的终末期肾病患者（CAPD-ESRD）的血清网膜素-1水平及其与临床特征和累积主要不良心脑血管事件（MACCE）风险的关系。共招募了290例CAPD-ESRD患者和50例健康对照者（HCs），采用酶联免疫吸附测定法检测他们的血清网膜素-1水平。对所有CAPD-ESRD患者进行36个月的随访，以评估累积MACCE发生率。CAPD-ESRD患者的网膜素-1水平低于HCs [中位数（四分位间距）：229.350（153.575 - 355.550）对449.800（354.125 - 527.450）pg/mL]（<0.001）。此外，网膜素-1水平与C反应蛋白（CRP）（=0.028）、总胆固醇（=0.023）和低密度脂蛋白胆固醇（=0.005）呈负相关，而在CAPD-ESRD患者中，网膜素-1水平与其他临床特征无相关性。CAPD-ESRD患者第一年、第二年和第三年的累积MACCE发生率分别为4.5%、13.1%和15.5%，网膜素-1水平高的CAPD-ESRD患者的累积MACCE发生率低于网膜素-1水平低的患者（=0.004）。此外，网膜素-1（风险比（HR）=0.422，=0.013）和高密度脂蛋白胆固醇（HR = 0.396，=0.010）与累积MACCE发生率降低独立相关；而年龄（HR = 3.034，=0.006）、腹膜透析时间（HR = 2.741，=0.006）、CRP（HR = 2.289，=0.026）、血清尿酸（HR = 2.538，=0.008）与CAPD-ESRD患者累积MACCE发生率升高独立相关。总之，血清网膜素-1水平高与CAPD-ESRD患者炎症减轻、血脂水平降低及累积MACCE风险降低相关。
