增强子共扩增和劫持促进脂肪肉瘤中癌基因的表达。
Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma.
机构信息
Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.
Department of Neurosurgery, Feinberg School of Medicine Northwestern University, Chicago, Illinois.
出版信息
Cancer Res. 2023 May 2;83(9):1517-1530. doi: 10.1158/0008-5472.CAN-22-1858.
Abstract
Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.
摘要
脂肪肉瘤增强子景观和 3D 基因组结构的综合分析鉴定了广泛的增强子-癌基因共扩增和增强子劫持事件，加深了对癌基因在癌症中如何调控的理解。
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