Ji Fengming, Wu Chengchuang, Li Ye, Zhanghuang Chenghao, Li Jinrong, Li Li, Yang Zhen, Yan Bing
Urology Surgery Department of Kunming Chlidren's Hospital, Xishan District, No. 288, Qianxing Road, Kunming, Yunnan, 650100, People's Republic of China.
Oncology Department of Kunming Children's Hospital, Kunming, Yunnan, 650100, People's Republic of China.
Pediatr Surg Int. 2023 Feb 27;39(1):141. doi: 10.1007/s00383-023-05408-y.
To analyze the efficacy of multidisciplinary treatment for Wilms tumor (WT) in Kunming Children's Hospital, and investigate the risk factors affecting the prognosis of WT.
The clinic-pathological data were collected and analyzed in patients with unilateral WT treated in Kunming Children's Hospital from January 2017 to July 2021. Research subjects were selected according to inclusion criteria and exclusion criteria. The risk factors and independent risk factors that affect the prognosis of patients with WT were determined by Kaplan-Meier survival analysis and Cox proportional hazards model, respectively.
A total of 68 children were included in this study, and the 5-year overall survival (OS) rate was 87.4%. Kaplan-Meier survival analysis results showed that ethnicity (P = 0.020), the tumor volume of resection (P = 0.001), histological type (P < 0.001), and postoperative recurrence (P < 0.001) were the risk factors affecting the prognosis of children with WT. The results of the Cox proportional hazards model showed that only the histological type (P = 0.018) was the independent risk factor for the prognosis of WT.
The efficacy of multidisciplinary treatment for WT was satisfying. The histological type has important predictive value for the prognosis of WT, and the patient with unfavorable histology has a poor prognosis.
分析昆明儿童医院多学科治疗肾母细胞瘤（WT）的疗效，并探讨影响WT预后的危险因素。
收集并分析2017年1月至2021年7月在昆明儿童医院接受治疗的单侧WT患者的临床病理资料。根据纳入标准和排除标准选择研究对象。分别采用Kaplan-Meier生存分析和Cox比例风险模型确定影响WT患者预后的危险因素和独立危险因素。
本研究共纳入68例儿童，5年总生存率（OS）为87.4%。Kaplan-Meier生存分析结果显示，种族（P = 0.020）、肿瘤切除体积（P = 0.001）、组织学类型（P < 0.001）和术后复发（P < 0.001）是影响WT患儿预后的危险因素。Cox比例风险模型结果显示，仅组织学类型（P = 0.018）是WT预后的独立危险因素。
WT多学科治疗疗效满意。组织学类型对WT预后具有重要的预测价值，组织学类型不良的患者预后较差。
