Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Neurology, Haukeland University Hospital, Bergen, Norway.
J Psychosom Res. 2023 May;168:111200. doi: 10.1016/j.jpsychores.2023.111200. Epub 2023 Feb 20.
Little is known about the association between antihypertensive drugs with mental health outcomes. We examined the association between the antihypertensive classes and other clinical patient features with symptoms of depression, anxiety, insomnia, and Post-Traumatic Stress Disorder (PTSD) in a cohort of Syrian war refugees with stress and hypertension residing in Jordan.
This cross-sectional study recruited hypertensive Syrian refugees with stress. Depression severity was assessed using the Patient Health Questionnaire-9, anxiety was measured by The General Anxiety Disorder-7, the Insomnia Severity Index was used to evaluate sleep quality and PTSD was measured using Davidson Trauma Scale. To investigate the association between the different classes of antihypertensive medication and mental health outcomes we used multivariable regression models.
Of the 492 participants, 251 were men (51%), 234 (47.6%) were on β-blockers, 141 (28.7%) on diuretics, and 209 (42.5%) on Angiotensin Converting Enzyme Inhibitors (ACEIs)/Angiotensin Receptor Blockers (ARBs). Although the multivariate regression revealed the different classes of antihypertensives are not associated with mental health symptoms, however, physical activity is associated with lower adjusted odds for symptoms of depression (0.68 (0.46-0.99), p = 0.04), anxiety (0.60 (0.42-0.85),p = 0.005), insomnia (0.63 (0.44-0.91),p = 0.01) and dyslipidemia (3.48(0.29-6.69),p = 0.03) is associated with higher PTSD symptoms.
The study subjects were not assessed for psychiatric diagnoses clinically. Further, we used a cross-sectional design that does not allow to measure longitudinal changes.
The association between antihypertensive drugs and mental health symptoms was not evident in the present study. Follow-up future studies are required.
关于降压药物与心理健康结果之间的关联知之甚少。我们在约旦居住的有压力和高血压的叙利亚战争难民队列中，检查了降压药类别与其他临床患者特征与抑郁、焦虑、失眠和创伤后应激障碍（PTSD）症状之间的关系。
本横断面研究招募了患有应激的高血压叙利亚难民。使用患者健康问卷-9 评估抑郁严重程度，使用一般焦虑症-7 评估焦虑，使用失眠严重程度指数评估睡眠质量，使用戴维森创伤量表评估 PTSD。为了研究不同类别的降压药物与心理健康结果之间的关系，我们使用了多变量回归模型。
在 492 名参与者中，有 251 名男性（51%），234 名（47.6%）服用β受体阻滞剂，141 名（28.7%）服用利尿剂，209 名（42.5%）服用血管紧张素转换酶抑制剂（ACEI）/血管紧张素受体阻滞剂（ARB）。尽管多变量回归显示不同类别的降压药与心理健康症状无关，但身体活动与抑郁症状的调整后比值比降低相关（0.68（0.46-0.99），p=0.04），焦虑（0.60（0.42-0.85），p=0.005），失眠（0.63（0.44-0.91），p=0.01）和血脂异常（3.48（0.29-6.69），p=0.03）与 PTSD 症状升高相关。
研究对象未进行临床评估精神病诊断。此外，我们使用了不允许测量纵向变化的横断面设计。
在本研究中，降压药物与心理健康症状之间的关联不明显。需要进行后续的未来研究。
