Automatic vessel crossing and bifurcation detection based on multi-attention network vessel segmentation and directed graph search.

Analysis of the vascular tree is the basic premise to automatically diagnose retinal biomarkers associated with ophthalmic and systemic diseases, among which accurate identification of intersection and bifurcation points is quite challenging but important for disentangling complex vascular network and tracking vessel morphology. In this paper, we present a novel directed graph search-based multi-attentive neural network approach to automatically segment the vascular network and separate intersections and bifurcations from color fundus images. Our approach uses multi-dimensional attention to adaptively integrate local features and their global dependencies while learning to focus on target structures at different scales to generate binary vascular maps. A directed graphical representation of the vascular network is constructed to represent the topology and spatial connectivity of the vascular structures. Using local geometric information including color difference, diameter, and angle, the complex vascular tree is decomposed into multiple sub-trees to finally classify and label vascular feature points. The proposed method has been tested on the DRIVE dataset and the IOSTAR dataset containing 40 images and 30 images, respectively, with 0.863 and 0.764 F-score of detection points and average accuracy of 0.914 and 0.854 for classification points. These results demonstrate the superiority of our proposed method outperforming state-of-the-art methods in feature point detection and classification.