Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia; Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia; Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
Environ Res. 2023 Jun 15;227:115578. doi: 10.1016/j.envres.2023.115578. Epub 2023 Feb 25.
Efforts to restrict the emergence and progression of multidrug-resistant bacterial strains should heavily involve the scientific community, including government bodies, researchers, and industries, in developing new and effective photocatalytic antimicrobial agents. Such changes warrant the modernization and upscaling of materials synthesis laboratories to support and expedite the mass production of materials at the industrial scale for the benefit of humankind and the environment. Despite the massive volume of publications reporting the potential usage of different types of metal-based nanomaterials as antimicrobial agents, reviews uncovering the similarities and differences among the various products remain lacking. This review details the basic and unique properties of metal-based nanoparticles, their use as photocatalytic antimicrobial agents, and their therapeutic modes of action. It shall be noted that compared to traditional antibiotics, the mode of action of photocatalytic metal-based nanomaterials for killing microorganisms are completely different, despite displaying promising performance against antibiotic-resistant bacteria. Besides, this review uncovers the differences in the mode of actions of metal oxide nanoparticles against different types of bacteria, as well as towards viruses. Last but not least, this review comprehensively describes previous published clinical trials and medical usages involving contemporary photocatalytic antimicrobial agents.
努力限制多药耐药细菌菌株的出现和进展应该大量涉及科学界，包括政府机构、研究人员和行业，以开发新的和有效的光催化抗菌剂。这些变化需要对材料合成实验室进行现代化和扩大规模，以支持和加快工业规模的材料大规模生产，造福人类和环境。尽管有大量出版物报告了不同类型的基于金属的纳米材料作为抗菌剂的潜在用途，但仍缺乏揭示各种产品之间相似性和差异性的综述。本综述详细介绍了基于金属的纳米粒子的基本和独特性质、它们作为光催化抗菌剂的用途以及它们的治疗作用模式。应当指出的是，与传统抗生素相比，光催化金属基纳米材料杀死微生物的作用模式完全不同，尽管它们对耐抗生素的细菌表现出有前景的性能。此外，本综述揭示了金属氧化物纳米粒子针对不同类型细菌以及针对病毒的作用模式的差异。最后但同样重要的是，本综述全面描述了以前发表的涉及当代光催化抗菌剂的临床试验和医疗用途。
