Patterson T L, Kaplan R M, Sallis J F, Nader P R
Division of General Pediatrics, University of California at San Diego, La Jolla 92093.
Prev Med. 1987 Sep;16(5):616-25. doi: 10.1016/0091-7435(87)90045-4.
We investigated the aggregation of blood pressure within 95 Anglo-American and 111 Mexican-American families. Degree of genetic relatedness was evaluated by calculating separate correlations for spouses and for each spouse with both same-sex and opposite-sex offspring. In addition, sibling correlations were evaluated. These analyses were performed separately for Anglo-American and Mexican-American families. Replicating earlier findings, correlations between blood pressures of Anglo spouses were nonsignificant. However, there were significant spousal correlations in the Mexican-American group. For Anglo-American families, there were significant associations between blood pressures of fathers and sons and between blood pressures of mothers and daughters. Correlations between blood pressures for opposite-sex parent-child pairs were nonsignificant. In the Mexican-American group, there were significant correlations between fathers' blood pressures and those of both male and female offspring. For mothers, blood pressures were weakly correlated with all other family members. These relationships remained after adjustment for age, body mass index, and measures of dietary habits and activity levels. In general, blood pressure aggregation was greater in Mexican-American families.
我们研究了95个英裔美国家庭和111个墨西哥裔美国家庭的血压聚集情况。通过计算配偶之间以及每个配偶与同性和异性后代之间的单独相关性来评估遗传相关程度。此外，还评估了兄弟姐妹之间的相关性。这些分析分别在英裔美国家庭和墨西哥裔美国家庭中进行。重复早期的研究结果，英裔美国家庭配偶的血压之间的相关性不显著。然而，在墨西哥裔美国家庭组中，配偶之间存在显著的相关性。对于英裔美国家庭，父亲与儿子的血压之间以及母亲与女儿的血压之间存在显著关联。异性亲子对的血压之间的相关性不显著。在墨西哥裔美国家庭组中，父亲的血压与男性和女性后代的血压之间存在显著相关性。对于母亲来说，血压与所有其他家庭成员的相关性较弱。在对年龄、体重指数以及饮食习惯和活动水平进行调整后，这些关系仍然存在。总体而言，墨西哥裔美国家庭的血压聚集性更强。
