细胞骨架在肾上腺髓质分泌中的作用。

The role of cytoskeleton in adreno-medullary secretion.

作者信息

Cooke P H, Poisner A M

出版信息

Methods Achiev Exp Pathol. 1979;9:137-46.

Abstract

Chromaffin cells of the adrenal medulla contain prominent arrays of microtubules and microfilaments. One population of microtubules radiates from the cytocentrum and permeates the areas of the cytoplasm containing chromaffin granules; the other population of microtubules forms a subplasmalemmal network together with actin-like microfilaments. Hence, the cytoskeletal elements in chromaffin cells are strategically located to participate in the mobility of chromaffin granules to the cell surface and to regulate access of the granules to the plasma membrane during exocytosis. Agents which effect the integrity of the cytoskeleton clearly affect the secretory process in a manner which indicates that the microtubules and microfilaments play an active role in the release process.

摘要

肾上腺髓质的嗜铬细胞含有显著的微管和微丝阵列。其中一组微管从细胞中心放射状伸出，贯穿含有嗜铬颗粒的细胞质区域；另一组微管则与肌动蛋白样微丝一起形成质膜下网络。因此，嗜铬细胞中的细胞骨架成分处于关键位置，参与嗜铬颗粒向细胞表面的移动，并在胞吐作用期间调节颗粒与质膜的接触。影响细胞骨架完整性的物质明显以一种表明微管和微丝在释放过程中发挥积极作用的方式影响分泌过程。